Using data from Fermilab fixed-target experiment E791, we have measured particle-antiparticle production asymmetries for lambda zero, cascade minus, and omega minus hyperons in pi minus-nucleon interactions at 500 GeV/c. The asymmetries are measured as functions of Feynman-x (x_F) and pt^2 over the ranges of -0.12 GE x_F LE 0.12 and 0 GE pt^2 LE 4 (GeV/c)^2. We find substantial asymmetries, even at x_F = 0. We also observe leading-particle- type asymmetries which qualitatively agree with theoretical predictions.