This Letter presents measurements of the nucleon structure function F2(x,Q2) based on the deep-inelastic scattering of 215- and 93-GeV muons in the iron multimuon spectrometer at Fermilab. With use of a lowest-order QCD calculation, a value of ΛLO=230±40(stat.)±80(syst.) MeV/c is found.

The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (PbPb) collisions at a center-of-mass energy of $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV per nucleon pair, using the decay chain X(3872) $\to$ J$/\psi\, \pi^+\pi^- \to$ $\mu^+\mu^-\pi^+\pi^-$. The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb$^{-1}$. The measurement is performed in the rapidity and transverse momentum ranges $|y|$ $\lt$ 1.6 and 15 $\lt$ $p_\mathrm{T}$ $\lt$ 50 GeV$/c$. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to $\psi$(2S) yield ratio is found to be $\rho^\mathrm{PbPb} = $ 1.08 $\pm$ 0.49 (stat) $\pm$ 0.52 (syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.

Production cross sections of $\Upsilon$(1S), $\Upsilon$(2S), and $\Upsilon$(3S) states decaying into $\mu^+\mu^-$ in proton-lead (pPb) collisions are reported using data collected by the CMS experiment at $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV. A comparison is made with corresponding cross sections obtained with pp data measured at the same collision energy and scaled by the Pb nucleus mass number. The nuclear modification factor for $\Upsilon$(1S) is found to be $R_\mathrm{pPb}(\Upsilon(1S))$ = 0.806 $\pm$ 0.024 (stat) $\pm$ 0.059 (syst). Similar results for the excited states indicate a sequential suppression pattern, such that $R_\mathrm{pPb}(\Upsilon(1S))$$\gt$$R_\mathrm{pPb}(\Upsilon(2S))$$\gt$$R_\mathrm{pPb}(\Upsilon(3S))$. The suppression is much less pronounced in pPb than in PbPb collisions, and independent of transverse momentum $p_\mathrm{T}^\Upsilon$ and center-of-mass rapidity $y_\mathrm{CM}^\Upsilon$ of the individual $\Upsilon$ state in the studied range $p_\mathrm{T}^\Upsilon$$\lt$ 30 GeV$/c$ and $\vert y_\mathrm{CM}^\Upsilon\vert$$\lt$ 1.93. Models that incorporate sequential suppression of bottomonia in pPb collisions are in better agreement with the data than those which only assume initial-state modifications.

The momentum-weighted sum of the electric charges of particles inside a jet, known as jet charge, is sensitive to the electric charge of the particle initiating the parton shower. This paper presents jet charge distributions in $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV lead-lead (PbPb) and proton-proton (pp) collisions recorded with the CMS detector at the LHC. These data correspond to integrated luminosities of 404 $\mu$b$^{-1}$ and 27.4 pb$^{-1}$ for PbPb and pp collisions, respectively. Leveraging the sensitivity of the jet charge to fundamental differences in the electric charges of quarks and gluons, the jet charge distributions from simulated events are used as templates to extract the quark- and gluon-like jet fractions from data. The modification of these jet fractions is examined by comparing pp and PbPb data as a function of the overlap of the colliding Pb nuclei (centrality). This measurement tests the color charge dependence of jet energy loss due to interactions with the quark-gluon plasma. No significant modification between different centrality classes and with respect to pp results is observed in the extracted fractions of quark- and gluon-like jet fractions.

The transverse energy ($E_\mathrm{T}^{\gamma}$) spectra of photons isolated from other particles are measured using proton-proton (pp) and lead-lead (PbPb) collisions at the LHC at $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV with integrated luminosities of 27.4 pb$^{-1}$and 404 $\mu$b$^{-1}$ for pp and PbPb data, respectively. The results are presented for photons with 25 $<$ $E_\mathrm{T}^{\gamma}$ $<$ 200 GeV in the pseudorapidity range $|\eta|$ $<$ 1.44, and for different centrality intervals for PbPb collisions. Photon production in PbPb collisions is consistent with that in pp collisions scaled by the number of binary nucleon-nucleon collisions, demonstrating that photons do not interact with the quark-gluon plasma. Therefore, isolated photons can provide information about the initial energy of the associated parton in photon+jet measurements. The results are compared with predictions from the next-to-leading-order JETPHOX generator for different parton distribution functions (PDFs) and nuclear PDFs (nPDFs). The comparisons can help to constrain the nPDFs global fits.

Measurements of the second Fourier harmonic coefficient ($v_2$) of the azimuthal distributions of prompt and nonprompt D$^0$ mesons produced in pp and pPb collisions are presented. Nonprompt D$^0$ mesons come from beauty hadron decays. The data samples are collected by the CMS experiment at nucleon-nucleon center-of-mass energies of 13 and 8.16 TeV, respectively. In high multiplicity pp collisions, $v_2$ signals for prompt charm hadrons are reported for the first time, and are found to be comparable to those for light-flavor hadron species over a transverse momentum ($p_\mathrm{T}$) range of 2-6 GeV. Compared at similar event multiplicities, the prompt D$^0$ meson $v_2$ values in pp and pPb collisions are similar in magnitude. The $v_2$ values for open beauty hadrons are extracted for the first time via nonprompt D$^0$ mesons in pPb collisions. For $p_\mathrm{T}$ in the range of 2-5 GeV, the results suggest that $v_2$ for nonprompt D$^0$ mesons are smaller than those for prompt D$^0$ mesons. These new measurements indicate a positive charm hadron $v_2$ in pp collisions and suggest a mass dependence in $v_2$ between charm and beauty hadrons in the pPb system. These results provide insights into the origin of heavy-flavor quark collectivity in small systems.

The second-order Fourier coefficients ($v_2$) characterizing the azimuthal distribution of $\Upsilon$(1S) and $\Upsilon$(2S) mesons arising from PbPb collisions at $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV are studied. The $\Upsilon$ mesons are reconstructed in their dimuon decay channel, as measured by the CMS detector. The data set corresponds to an integrated luminosity of 1.7 nb$^{-1}$. The scalar product method is used to extract the $v_2$ coefficients of the azimuthal distribution. Results are reported for the rapidity range $|y|$$\lt$ 2.4, with the transverse momentum 0 $\lt$$p_\mathrm{T}$$\lt$ 50 GeV/$c$, and in three centrality ranges of 10-30%, 30-50% and 50-90%. In contrast to the J/$\psi$ mesons, the measured $v_2$ values for the $\Upsilon$ mesons are found to be consistent with zero.

Jet production in lead-lead (PbPb) and proton-proton (pp) collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV is studied with the CMS detector at the LHC, using PbPb and pp data samples corresponding to integrated luminosities of 404 $\mu$b$^{-1}$ and 27.4 pb$^{-1}$, respectively. Jets with different areas are reconstructed using the anti-$k_\mathrm{T}$ algorithm by varying the distance parameter $R$. The measurements are performed using jets with transverse momenta ($p_\mathrm{T}$) greater than 200 GeV and in a pseudorapidity range of $|\eta|$$\lt$ 2. To reveal the medium modification of the jet spectra in PbPb collisions, the properly normalized ratio of spectra from PbPb and pp data is used to extract jet nuclear modification factors as functions of the PbPb collision centrality, $p_\mathrm{T}$ and, for the first time, as a function of $R$ up to 1.0. For the most central collisions, a strong suppression is observed for high-$p_\mathrm{T}$ jets reconstructed with all distance parameters, implying that a significant amount of jet energy is scattered to large angles. The dependence of jet suppression on $R$ is expected to be sensitive to both the jet energy loss mechanism and the medium response, and so the data are compared to several modern event generators and analytic calculations. The models considered do not fully reproduce the data.

Anisotropies in the initial energy density distribution of the quark-gluon plasma created in high energy heavy ion collisions lead to anisotropies in the azimuthal distributions of the final-state particles known as collective flow. Fourier harmonic decomposition is used to quantify these anisotropies. The higher-order harmonics can be induced by the same order anisotropies (linear response) or by the combined influence of several lower order anisotropies (nonlinear response) in the initial state. The mixed higher-order anisotropic flow and nonlinear response coefficients of charged particles are measured as functions of transverse momentum and centrality in PbPb collisions at nucleon-nucleon center-of-mass energies $\sqrt{s_\mathrm{NN}} =$ 2.76 and 5.02 TeV with the CMS detector. The results are compared with viscous hydrodynamic calculations using several different initial conditions, as well as microscopic transport model calculations. None of the models provides a simultaneous description of the mixed higher-order flow harmonics and nonlinear response coefficients.

Evidence for the light-by-light scattering process, $\gamma\gamma$ $\to$ $\gamma\gamma$, in ultraperipheral PbPb collisions at a centre-of-mass energy per nucleon pair of 5.02 TeV is reported. The analysis is conducted using a data sample corresponding to an integrated luminosity of 390 $\mu$b$^{-1}$ recorded by the CMS experiment at the LHC. Light-by-light scattering processes are selected in events with two photons exclusively produced, each with transverse energy E$_\mathrm{T}^{\gamma}$ $>$ 2 GeV, pseudorapidity $|\eta^{\gamma}|$ $\lt$ 2.4, diphoton invariant mass $m^{\gamma\gamma}$ $\gt$ 5 GeV, diphoton transverse momentum $p_\mathrm{T}^{\gamma\gamma}$ $\lt$ 1 GeV, and diphoton acoplanarity below 0.01. After all selection criteria are applied, 14 events are observed, compared to expectations of 9.0 $\pm$ 0.9 (theo) events for the signal and 4.0 $\pm$ 1.2 (stat) for the background processes. The excess observed in data relative to the background-only expectation corresponds to a significance of 3.7 standard deviations, and has properties consistent with those expected for the light-by-light scattering signal. The measured fiducial light-by-light scattering cross section, $\sigma_\mathrm{fid} (\gamma\gamma$ $\to$ $\gamma\gamma) =$ 120 $\pm$ 46 (stat) $\pm$ 28 (syst) $\pm$ 12 (theo) nb, is consistent with the standard model prediction. The $m^{\gamma\gamma}$ distribution is used to set new exclusion limits on the production of pseudoscalar axion-like particles, via the $\gamma\gamma$ $\to$ a $\to$ $\gamma\gamma$ process, in the mass range $m_{\mathrm{a}} =$ 5-90 GeV.

The differential production cross sections of B+/- mesons are measured via the exclusive decay channels B+/- to J/psi K+/- to mu+ mu- K+/- as a function of transverse momentum in pp and PbPb collisions at a center-of-mass energy sqrt(s[NN]) = 5.02 TeV per nucleon pair with the CMS detector at the LHC. The pp (PbPb) dataset used for this analysis corresponds to an integrated luminosity of 28.0 inverse picobarns (351 inverse microbarns). The measurement is performed in the B+/- meson transverse momentum range of 7 to 50 GeV/c, in the rapidity interval abs(y) < 2.4. In this kinematic range, a strong suppression of the production cross section by about a factor of two is observed in the PbPb system in comparison to the expectation from pp reference data. These results are found to be roughly compatible with theoretical calculations incorporating beauty quark diffusion and energy loss in a quark-gluon plasma.

Interactions between jets and the quark-gluon plasma produced in heavy ion collisions are studied via the angular distributions of summed charged-particle transverse momenta (pt) with respect to both the leading and subleading jet axes in high-pt dijet events. The contributions of charged particles in different momentum ranges to the overall event pt balance are decomposed into short-range jet peaks and a long-range azimuthal asymmetry in charged-particle pt. The results for PbPb collisions are compared to those in pp collisions using data collected in 2011 and 2013, at collision energy sqrt(s[NN]) = 2.76 TeV with integrated luminosities of 166 inverse microbarns and 5.3 inverse picobarns, respectively, by the CMS experiment at the LHC. Measurements are presented as functions of PbPb collision centrality, charged-particle pt, relative azimuth, and radial distance from the jet axis for balanced and unbalanced dijets.

Measurements of two- and multi-particle angular correlations in pp collisions at sqrt(s) = 5, 7, and 13 TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0 inverse picobarn (5 TeV), 6.2 inverse picobarns (7 TeV), and 0.7 inverse picobarns (13 TeV), were collected using the CMS detector at the LHC. The second-order (v[2]) and third-order (v[3]) azimuthal anisotropy harmonics of unidentified charged particles, as well as v[2] of K0 short and Lambda/anti-Lambda particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the v[2] values of charged hadrons (mostly pions), K0 short, and Lambda/anti-Lambda, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below pt of about 2 GeV/c. For 13 TeV data, the v[2] signals are also extracted from four- and six-particle correlations for the first time in pp collisions, with comparable magnitude to those from two-particle correlations. These observations are similar to those seen in pPb and PbPb collisions, and support the interpretation of a collective origin for the observed long-range correlations in high-multiplicity pp collisions.

The second- and third-order azimuthal anisotropy Fourier harmonics of charged particles produced in pPb collisions, at $\sqrt{s_\mathrm{NN}} =$ 8.16 TeV, are studied over a wide range of event multiplicities. Multiparticle correlations are used to isolate global properties stemming from the collision overlap geometry. The second-order "elliptic" harmonic moment is obtained with high precision through four-, six-, and eight-particle correlations and, for the first time, the third-order "triangular" harmonic moment is studied using four-particle correlations. A sample of peripheral PbPb collisions at $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV that covers a similar range of event multiplicities as the pPb results is also analyzed. Model calculations of initial-state fluctuations in pPb and PbPb collisions can be directly compared to the high precision experimental results. This work provides new insight into the fluctuation-driven origin of the $v_3$ coefficients in pPb and PbPb collisions, and into the dominating overall collision geometry in PbPb collisions at the earliest stages of heavy ion interactions.

The relative yields of $\Upsilon$ mesons produced in pp and PbPb collisions at $\sqrt{s_\mathrm{NN}}$ = 5.02 TeV and reconstructed via the dimuon decay channel are measured using data collected by the CMS experiment. Double ratios are formed by comparing the yields of the excited states, $\Upsilon$(2S) and $\Upsilon$(3S), to the ground state, $\Upsilon$(1S), in both PbPb and pp collisions at the same center-of-mass energy. The double ratios, [$\Upsilon$(nS)/$\Upsilon$(1S)]$_\mathrm{PbPb}$ / [$\Upsilon$(nS)/$\Upsilon$(1S)]$_\mathrm{pp}$, are measured to be 0.308 $\pm$ 0.055 (stat) $\pm$ 0.019 (syst) for the $\Upsilon$(2S) and less than 0.26 at 95% confidence level for the $\Upsilon$(3S). No significant $\Upsilon$(3S) signal is found in the PbPb data. The double ratios are studied as a function of collision centrality, as well as dimuon transverse momentum and rapidity. No significant dependencies are observed.

Measurements of prompt $\psi$(2S) meson production cross sections in proton-lead (pPb) and proton-proton (pp) collisions at a nucleon-nucleon center-of-mass energy of $\sqrt{s_{_\mathrm{NN}}}=$ 5.02 TeV are reported. The results are based on pPb and pp data collected by the CMS experiment at the LHC, corresponding to integrated luminosities of 34.6 nb$^{-1}$ and 28.0 pb$^{-1}$, respectively. The nuclear modification factor $R_\mathrm{pPb}$ is measured for prompt $\psi$(2S) in the transverse momentum range 4 $<$ p$_\mathrm{T}$ $<$ 30 GeV$/c$ and the center-of-mass rapidity range $-$2.4 $< y_\mathrm{cm} <$ 1.93. The results on $\psi$(2S) $R_\mathrm{pPb}$ are compared to the corresponding modification factor for prompt J$/\psi$ mesons and are found to be more suppressed than the J$/\psi$ states over the entire kinematic range studied.

The quark-gluon plasma is studied via medium-induced changes to correlations between jets and charged particles in PbPb collisions compared to pp reference data. This analysis uses data sets from PbPb and pp collisions with integrated luminosities of 166 inverse microbarns and 5.3 inverse picobarns, respectively, collected at sqrt(s[NN]) = 2.76 TeV. The angular distributions of charged particles are studied as a function of relative pseudorapidity (Delta eta) and relative azimuthal angle (Delta phi) with respect to reconstructed jet directions. Charged particles are correlated with all jets with transverse momentum (pt) above 120 GeV, and with the leading and subleading jets (the highest and second-highest in pt, respectively) in a selection of back-to-back dijet events. Modifications in PbPb data relative to pp reference data are characterized as a function of PbPb collision centrality and charged particle pt. A centrality-dependent excess of low-pt particles is present for all jets studied, and is most pronounced in the most central events. This excess of low-pt particles follows a Gaussian-like distribution around the jet axis, and extends to large relative angles of Delta eta approximately 1 and Delta phi approximately 1.

The spectra of charged particles produced within the pseudorapidity window abs(eta) < 1 at sqrt(s[NN]) = 5.02 TeV are measured using 404 inverse microbarns of PbPb and 27.4 inverse picobarns of pp data collected by the CMS detector at the LHC in 2015. The spectra are presented over the transverse momentum ranges spanning 0.5 < pt < 400 GeV in pp and 0.7 < pt < 400 GeV in PbPb collisions. The corresponding nuclear modification factor, R[AA], is measured in bins of collision centrality. The R[AA] in the 5% most central collisions shows a maximal suppression by a factor of 7-8 in the pt region of 6-9 GeV. This dip is followed by an increase, which continues up to the highest pt measured, and approaches unity in the vicinity of pt = 200 GeV. The R[AA] is compared to theoretical predictions and earlier experimental results at lower collision energies. The newly measured pp spectrum is combined with the pPb spectrum previously published by the CMS Collaboration to construct the pPb nuclear modification factor, R[pA], up to 120 GeV. For pt > 20 GeV, R[pA] exhibits weak momentum dependence and shows a moderate enhancement above unity.

The CMS Collaboration presents the first measurement of the differential cross section of jets from charm quarks produced in proton-lead (pPb) collisions at a nucleon-nucleon center-of-mass energy of sqrt(s[NN]) = 5.02 TeV, as well as results from charm quark jets in proton-proton (pp) collisions at sqrt(s) = 2.76 and 5.02 TeV. By comparing the yields of the pPb and pp collision systems at the same energy, a nuclear modification factor for charm jets from 55 to 400 GeV/c in pPb collisions at sqrt(s[NN]) = 5.02 TeV of R[pA] = 0.92 +/- 0.07 (stat) +/- 0.11 (syst) is obtained. This is consistent with an absence of final-state energy loss for charm quarks in pPb collisions. In addition, the fraction of jets coming from charm quarks is found to be consistent with that predicted by PYTHIA 6 for pp collisions at sqrt(s)= 2.76 and 5.02 TeV, and is independent of the jet transverse momentum from 55 to 400 GeV/c.

The production of jets in association with Z bosons, reconstructed via the mu+mu- and e+e- decay channels, is studied in pp and, for the first time, in PbPb collisions. Both data samples were collected by the CMS experiment at the LHC, at a nucleon-nucleon center-of-mass energy of 5.02 TeV. The PbPb collisions were analyzed in the 0-30% centrality range. The back-to-back azimuthal alignment was studied in both pp and PbPb collisions for Z bosons with transverse momentum p[tz] > 60 GeV/c and a recoiling jet with p[tj] > 30 GeV/c. The pt imbalance, x[jz] = p[tj] / p[tz], as well as the average number of jet partners per Z, R[jz], were studied in intervals of p[tz], in both pp and PbPb collisions. The R[jz] is found to be smaller in PbPb than in pp collisions, which suggests that in PbPb collisions a larger fraction of partons, associated with the Z bosons, lose energy and fall below the 30 GeV/c p[tj] threshold.

The relative modification of the prompt psi(2S) and J/psi yields from pp to PbPb collisions, at the center of mass energy of 5.02 TeV per nucleon pair, is presented. The analysis is based on pp and PbPb data samples collected by the CMS experiment at the LHC in 2015, corresponding to integrated luminosities of 28.0 inverse picobarns and 464 inverse microbarns, respectively. The double ratio of measured yields of prompt charmonia reconstructed through their decays into muon pairs, (N[psi(2S)]/N[J/psi])[PbPb] / (N[psi(2S)]/N[J/psi])[pp], is determined as a function of PbPb collision centrality and charmonium transverse momentum pt, in two kinematic intervals: abs(y) < 1.6 covering 6.5 < pt < 30 GeV/c and 1.6 < abs(y) < 2.4 covering 3 < pt < 30 GeV/c. The centrality-integrated double ratios are 0.36 +/- 0.08 (stat) +/-0.05 (syst) in the first interval and 0.24 +/- 0.22 (stat) +/- 0.09 (syst) in the second. The double ratio is lower than unity in all the measured bins, suggesting that the psi(2S) yield is more suppressed than the J/psi yield in the explored phase space.

This paper reports the measurement of J/psi meson production in proton-proton (pp) and proton-lead (pPb) collisions at a center-of-mass energy per nucleon pair of 5.02 TeV by the CMS experiment at the LHC. The data samples used in the analysis correspond to integrated luminosities of 28 inverse picobarns and 35 inverse nanobarns for pp and pPb collisions, respectively. Prompt and nonprompt J/psi mesons, the latter produced from the decay of B mesons, are measured in their dimuon decay channels. Differential cross sections are measured in the transverse momentum range of 2 < pt < 30 GeV/c, and center-of-mass rapidity ranges of abs(y[CM]) < 2.4 (pp) and -2.87 < y[CM] < 1.93 (pPb). The nuclear modification factor, R[pPb], is measured as functions of both pt and y[CM]. Small modifications of the J/psi cross sections are observed in pPb relative to pp collisions. The ratio of J/psi production cross sections in p-going and Pb-going directions, R[FB], studied as functions of pt and y[CM], shows a significant decrease for increasing transverse energy deposited at large pseudorapidities. These results, which cover a wide kinematic range, provide new insight on the role of cold nuclear matter effects on prompt and nonprompt J/psi production.

The differential cross sections of $\Lambda_\mathrm{c}^+$ baryon production are measured via the exclusive decay channel $\Lambda_\mathrm{c}^+ \to $pK$^-\pi^+$, as a function of transverse momentum ($p_\mathrm{T}$) in proton-proton (pp) and lead-lead (PbPb) collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV with the CMS detector at the LHC. The measurement is performed within the $\Lambda_\mathrm{c}^+$ rapidity interval $|y|<$1.0 in the $p_\mathrm{T}$ range of 5-20 GeV/$c$ in pp and 10-20 GeV/$c$ in PbPb collisions. The observed yields of $\Lambda_\mathrm{c}^+$ for $p_\mathrm{T}$ of 10-20 GeV/$c$ suggest a possible suppression in central PbPb collisions compared to pp collisions. The $\Lambda_\mathrm{c}^+/$D$^0$ production ratio in pp collisions is compared to theoretical models. In PbPb collisions, this ratio is consistent with the result from pp collisions in their common $p_\mathrm{T}$ range.

The prompt D$^0$ meson azimuthal anisotropy coefficients, $v_2$ and $v_3$, are measured at midrapidity ($|y| < 1.0$) in PbPb collisions at a center-of-mass energy $\sqrt{s_\mathrm{NN}} = $5.02 TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum ($p_\mathrm{T}$) range of 1 to 40 GeV/c, for central and midcentral collisions. The $v_2$ coefficient is found to be positive throughout the $p_\mathrm{T}$ range studied. The first measurement of the prompt D$^0$ meson $v_3$ coefficient is performed, and values up to 0.07 are observed for $p_\mathrm{T}$ around 4 GeV/c. Compared to measurements of charged particles, a similar $p_\mathrm{T}$ dependence, but smaller magnitude for $p_\mathrm{T} < $6 GeV/c, is found for prompt D$^0$ meson $v_2$ and $v_3$ coefficients. The results are consistent with the presence of collective motion of charm quarks at low $p_\mathrm{T}$ and a path length dependence of charm quark energy loss at high $p_\mathrm{T}$, thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.

The first observation of top quark production in proton-nucleus collisions is reported using proton-lead data collected by the CMS experiment at the CERN LHC at a nucleon-nucleon center-of-mass energy of sqrt(s[NN]) = 8.16 TeV. The measurement is performed using events with exactly one isolated electron or muon and at least four jets. The data sample corresponds to an integrated luminosity of 174 inverse nanobarns. The significance of the tt-bar signal against the background-only hypothesis is above five standard deviations. The measured cross section is sigma[tt-bar] = 45 +/- 8 nb, consistent with predictions from perturbative quantum chromodynamics.