A search is presented for the production of a Higgs boson in association with a single top quark, based on data collected in 2016 by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV, which corresponds to an integrated luminosity of 35.9 fb$^{-1}$. The production cross section for this process is highly sensitive to the absolute values of the top quark Yukawa coupling, $y_t$, the Higgs boson coupling to vector bosons, $g_\mathrm{HVV}$, and, uniquely, to their relative sign. Analyses using multilepton signatures, targeting H $\to$ WW, H $\to$ $\tau\tau$, and H $\to$ ZZ decay modes, and signatures with a single lepton and a $\mathrm{b\overline{b}}$ pair, targeting the H $\to$ $\mathrm{b\overline{b}}$ decay, are combined with a reinterpretation of a measurement in the H $\to$ $\gamma\gamma$ channel to constrain $y_\mathrm{t}$. For a standard model-like value of $g_\mathrm{HVV}$, the data favor positive values of $y_\mathrm{t}$ and exclude values of $y_\mathrm{t}$ below about $-$0.9 $y_\mathrm{t}^\mathrm{SM}$.
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