Measurements of the cross-section for producing \bquark quarks in the reaction $pp\to b\bar{b} X$ are reported in 7 and 13 TeV collisions at the LHC as a function of the pseudorapidity $\eta$ in the range $2<\eta<5$ covered by the acceptance of the LHCb experiment. The measurements are done using semileptonic decays of $b$-flavored hadrons decaying into a ground-state charmed hadron in association with a muon. The cross-sections in the covered $\eta$ range are $72.0\pm 0.3\pm6.8~\mu$b and $144\pm 1\pm 21~\mu$b for 7 and 13 TeV. The ratio is $2.00\pm0.02\pm0.26$, where the quoted uncertainties are statistical and systematic, respectively. The agreement with theoretical expectation is good at 7 TeV, but differs somewhat at 13 TeV. The measured ratio of cross-sections is larger at lower $\eta$ than the model prediction.

Production cross-sections of prompt charm mesons are measured using data from $pp$ collisions at the LHC at a centre-of-mass energy of $5\,$TeV. The data sample corresponds to an integrated luminosity of $8.60\pm0.33\,$pb$^{-1}$ collected by the LHCb experiment. The production cross-sections of $D^0$, $D^+$, $D_s^+$, and $D^{*+}$ mesons are measured in bins of charm meson transverse momentum, $p_{\text{T}}$, and rapidity, $y$. They cover the rapidity range $2.0<y<4.5$ and transverse momentum ranges $0 < p_{\text{T}} < 10\, \text{GeV}/c$ for $D^0$ and $D^+$ and $1 < p_{\text{T}} < 10\, \text{GeV}/c$ for $D_s^+$ and $D^{*+}$ mesons. The inclusive cross-sections for the four mesons, including charge-conjugate states, within the range of $1 < p_{\text{T}} < 8\, \text{GeV}/c$ are determined to be \sigma(pp\rightarrow D^0 X) = 1004 \pm 3 \pm 54\,\mu\text{b} \sigma(pp\rightarrow D^+ X) = 402 \pm 2 \pm 30\,\mu\text{b} \sigma(pp\rightarrow D_s^+ X) = 170 \pm 4 \pm 16\,\mu\text{b} \sigma(pp\rightarrow D^{*+} X)= 421 \pm 5 \pm 36\,\mu\text{b} where the uncertainties are statistical and systematic, respectively.

The production of $J/\psi$ mesons in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=13$ TeV is studied with the \lhcb detector. Cross-section measurements are performed as a function of the transverse momentum $p_\mathrm{T}$ and the rapidity $y$ of the $J/\psi$ meson in the region $p_\mathrm{T}<14\mathrm{GeV}/c$ and $2.0<y<4.5$, for both prompt $J/\psi$ mesons and $J/\psi$ mesons from $b$-hadron decays. The production cross-sections integrated over the kinematic coverage are $15.03\pm 0.03\pm 0.94$ $\mu$b for prompt $J/\psi$ and $2.25\pm 0.01\pm 0.14$ $\mu$b for $J/\psi$ from $b$-hadron decays, assuming zero polarization of the $J/\psi$ meson. The first uncertainties are statistical and the second systematic. The cross-section reported for $J/\psi$ mesons from $b$-hadron decays is used to extrapolate to a total $b\bar{b}$ cross-section. The ratios of the cross-sections with respect to $\sqrt{s}=8$ TeV are also determined.

Production cross-sections of prompt charm mesons are measured with the first data from $pp$ collisions at the LHC at a centre-of-mass energy of $13\,\mathrm{TeV}$. The data sample corresponds to an integrated luminosity of $4.98 \pm 0.19\,\mathrm{pb}^{-1}$ collected by the LHCb experiment. The production cross-sections of $D^{0}$, $D^{+}$, $D_{s}^{+}$, and $D^{*+}$ mesons are measured in bins of charm meson transverse momentum, $p_{\mathrm{T}}$, and rapidity, $y$, and cover the range $0 < p_{\mathrm{T}} < 15\,\mathrm{GeV}/c$ and $2.0 < y < 4.5$. The inclusive cross-sections for the four mesons, including charge conjugation, within the range of $1 < p_{\mathrm{T}} < 8\,\mathrm{GeV}/c$ are found to be \begin{equation} \sigma(pp \to D^{0} X) = 2072 \pm 2 \pm 124\,\mu\mathrm{b}\\ \sigma(pp \to D^{+} X) = 834 \pm 2 \pm \phantom{1}78\,\mu\mathrm{b}\\ \sigma(pp \to D_{s}^{+} X) = 353 \pm 9 \pm \phantom{1}76\,\mu\mathrm{b}\\ \sigma(pp \to D^{*+} X) = 784 \pm 4 \pm \phantom{1}87\,\mu\mathrm{b} \end{equation} where the uncertainties are due to statistical and systematic uncertainties, respectively.

Using a data sample corresponding to an integrated luminosity of $2.0\,fb^{-1}$, collected by the LHCb experiment, the production of the $\eta_c(1S)$ state in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=13 \text{ TeV}$ is studied in the rapidity range ${2.0 < y < 4.5}$ and in the transverse momentum range ${6.5 < p_{T} < 14.0\text{ GeV}}$. The cross-section for prompt production of $\eta_c(1S)$ mesons relative to that of the $J/\psi$ meson is measured using the ${p\bar{p}}$ decay mode and is found to be ${\sigma_{\eta_c(1S)}/\sigma_{J/\psi} = 1.69 \pm 0.15 \pm 0.10 \pm 0.18}$. The quoted uncertainties are, in order, statistical, systematic and due to uncertainties on the branching fractions of the ${J/\psi\to p \bar{p}}$ and ${\eta_c\to p \bar{p}}$ decays. The prompt $\eta_c(1S)$ production cross-section is determined to be ${\sigma_{\eta_c(1S)} = 1.26 \pm 0.11\pm 0.08 \pm 0.14 \,\mu b}$, where the last uncertainty includes that on the ${J/\psi}$ meson cross-section. The ratio of the branching fractions of $b$-hadron decays to the $\eta_c(1S)$ and ${J/\psi}$ states is measured to be ${\mathcal{B}_{b\to\eta_c X}/\mathcal{B}_{b\to J/\psi X} = 0.48 \pm 0.03 \pm 0.03 \pm 0.05}$, where the last uncertainty is due to those on the branching fractions of the ${J/\psi \to p \bar{p}}$ and ${\eta_c\to p \bar{p}}$ decays. The difference between the ${J/\psi}$ and $\eta_c(1S)$ masses is also determined to be ${113.0 \pm 0.7 \pm 0.1\text{ MeV}}$, which is the most precise single measurement of this quantity to date.

A measurement of the production cross-section of Z bosons in pp collisions at $\sqrt{s} = 13$ TeV is presented using dimuon and dielectron final states in LHCb data. The cross-section is measured for leptons with pseudorapidities in the range $2.0 < \eta < 4.5$, transverse momenta $p_\text{T} > 20$ GeV and dilepton invariant mass in the range $60<m(\ell\ell)<120$ GeV. The integrated cross-section from averaging the two final states is \begin{equation*}\sigma_{\text{Z}}^{\ell\ell} = 194.3 \pm 0.9 \pm 3.3 \pm 7.6\text{ pb,}\end{equation*} where the first uncertainty is statistical, the second is due to systematic effects, and the third is due to the luminosity determination. In addition, differential cross-sections are measured as functions of the Z boson rapidity, transverse momentum and the angular variable $\phi^*_\eta$.

The production cross-section of $J/\psi$ pairs is measured using a data sample of $pp$ collisions collected by the LHCb experiment at a centre-of-mass energy of $\sqrt{s} = 13 \,{\mathrm{TeV}}$, corresponding to an integrated luminosity of $279 \pm 11 \,{\mathrm{pb^{-1}}}$. The measurement is performed for $J/\psi$ mesons with a transverse momentum of less than $10 \,{\mathrm{GeV}}/c$ in the rapidity range $2.0<y<4.5$. The production cross-section is measured to be $15.2 \pm 1.0 \pm 0.9 \,{\mathrm{nb}}$. The first uncertainty is statistical, and the second is systematic. The differential cross-sections as functions of several kinematic variables of the $J/\psi$ pair are measured and compared to theoretical predictions.

Forward top quark pair production is studied in $pp$ collisions in the $\mu eb$ final state using a data sample corresponding to an integrated luminosity of 1.93 fb$^{-1}$ collected with the LHCb experiment at a centre-of-mass energy of 13 TeV. The cross-section is measured in a fiducial region where both leptons have a transverse momentum greater than 20 GeV and a pseudorapidity between 2.0 and 4.5. The quadrature sum of the azimuthal separation and the difference in pseudorapidities, denoted $\Delta R$, between the two leptons must be larger than 0.1. The $b$-jet axis is required to be separated from both leptons by a $\Delta R$ of 0.5, and to have a transverse momentum in excess of 20 GeV and a pseudorapidity between 2.2 and 4.2. The cross-section is measured to be $$\sigma_{t\bar{t}}= 126\pm19\,(\mathrm{stat})\pm16\,(\mathrm{syst})\pm5\,(\mathrm{lumi})\,\,\mathrm{ fb}$$ where the first uncertainty is statistical, the second is systematic, and the third is due to the luminosity determination. The measurement is compatible with the Standard Model prediction.

The production of $B^{\pm}$ mesons is studied in $pp$ collisions at centre-of-mass energies of 7 and 13 TeV, using $B^{\pm}\rightarrow J/\psi K^{\pm}$ decays and data samples corresponding to 1.0 fb$^{-1}$ and 0.3 fb$^{-1}$, respectively. The production cross-sections summed over both charges and integrated over the transverse momentum range $0<p_{\text{T}}< 40$ GeV/$c$ and the rapidity range $2.0<y<4.5$ are measured to be $\sigma(pp \rightarrow B^{\pm} X, \sqrt{s} = \text{7 TeV}) = 43.0 \pm 0.2 \pm 2.5 \pm 1.7\mu b,$ $\sigma(pp \rightarrow B^{\pm} X, \sqrt{s} = \text{13 TeV}) = 86.6 \pm 0.5 \pm 5.4 \pm 3.4\mu b,$ where the first uncertainties are statistical, the second are systematic, and the third are due to the limited knowledge of the $B^{\pm}\rightarrow J/\psi K^{\pm}$ branching fraction. The ratio of the cross-section at 13 TeV to that at 7 TeV is determined to be $2.02\pm0.02\text{(stat)}\pm0.12\text{(syst)}$. Differential cross-sections are also reported as functions of $p_{\text{T}}$ and $y$. All results are in agreement with theoretical calculations based on the state-of-art fixed next-to-leading order quantum chromodynamics.

The differential cross-section of prompt inclusive production of long-lived charged particles in proton-proton collisions is measured using a data sample recorded by the LHCb experiment at a centre-of-mass energy of ${\sqrt{s} = 13\,\mathrm{TeV}}$. The data sample, collected with an unbiased trigger, corresponds to an integrated luminosity of ${5.4\,\mathrm{nb}^{-1}}$. The differential cross-section is measured as a function of transverse momentum and pseudorapidity in the ranges ${p_\mathrm{T} \in [0.08, 10)\,\mathrm{GeV}\,c^{-1}}$ and ${\eta \in [2.0, 4.8)}$ and is determined separately for positively and negatively charged particles. The results are compared with predictions from various hadronic-interaction models.