We report on the production ofe± μ∓ pairs in 450 GeV/c pBe collisions at the CERN SPS. Theeμ signal, which has average missing energy of 21 GeV, is shown to be consistent with expectations from charm decay, and implies a σ ×B for\(c\bar c\) production in p-nucleon collisions of 0.63 ± 0.35μb. Alternatively, using an estimate of charm production from other experiments, the data imply a 95% confidence level upper limit of 1.16μb on any new physics process which producese±μ∓.