The first observation of μ + e + events produced in antineutrino interactions using the Fermilab 15 ft bubble chamber is reported. The relative yield of μ + e + events is (4.8 −3.2 +5.3 ) × 10 −4 of all charged-current events with antineutrino energy greater than 10 GeV. The observed V 0 rate is 1.0 −1.0 +1.2 per μ + e + event. Possible sources of these events are discussed.