We report on the charged-particle multiplicity dependence of net-proton cumulant ratios up to sixth order from $\sqrt{s}=200$ GeV $p$+$p$ collisions at the Relativistic Heavy Ion Collider (RHIC). The measured ratios $C_{4}/C_{2}$, $C_{5}/C_{1}$, and $C_{6}/C_{2}$ decrease with increased charged-particle multiplicity and rapidity acceptance. Neither the Skellam baselines nor PYTHIA8 calculations account for the observed multiplicity dependence. In addition, the ratios $C_{5}/C_{1}$ and $C_{6}/C_{2}$ approach negative values in the highest-multiplicity events, which implies that thermalized QCD matter may be formed in $p$+$p$ collisions.
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