The first measurements of the production of muons and electrons from heavy-flavour hadron decays in Xe-Xe collisions at $\sqrt{s_{\rm NN}}$ = 5.44 TeV, using the ALICE detector at the LHC, are reported. The measurement of the nuclear modification factor $R_{\rm AA}$ is performed as a function of transverse momentum $p_{\rm T}$ in several centrality classes at forward rapidity ($2.5 < y <4$) and midrapidity ($\vert y \vert < 0.8$) for muons and electrons from heavy-flavour hadron decays, respectively. A suppression by a factor up to about 2.5 compared to the binary-scaled pp reference is observed in central collisions at both central and forward rapidities. The $R_{\rm AA}$ of muons from heavy-flavour hadron decays is compared to previous measurements in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV. When the nuclear modification factors are compared in the centrality classes 0-10% for Xe-Xe collisions and 10-20% for Pb-Pb collisions, which have similar charged-particle multiplicity density, a similar suppression, with $R_{\rm AA} \sim 0.4$ in the $p_{\rm T}$ interval $4 < p_{\rm T} < 8$ GeV/$c$, is observed. The comparison of the measured $R_{\rm AA}$ values in the two collision systems brings new insights on the properties of the quark-gluon plasma by investigating the system-size and path-length dependence of medium-induced parton energy loss. The results of muons and electrons from heavy-flavour hadron decays provide new constraints to model calculations.

The production of $\Upsilon$ mesons in Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}}$ = 5 TeV is measured with the muon spectrometer of the ALICE detector at the LHC. The yields as well as the nuclear modification factors are determined in the forward rapidity region $2.5<y<4.0$, as a function of rapidity, transverse momentum and collision centrality. The results show that the production of the $\Upsilon$(1S) meson is suppressed by a factor of about three with respect to the production in proton-proton collisions. For the first time, a significant signal for the $\Upsilon$(2S) meson is observed at forward rapidity, indicating a suppression stronger by about a factor 2-3 with respect to the ground state. The measurements are compared with transport, hydrodynamic, comover and statistical hadronisation model calculations.

The inclusive J/$\psi$ meson production in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision of $\sqrt{s_{\rm NN}}$ = 5.02 TeV at midrapidity ($|y|$ < 0.9) is reported by the ALICE Collaboration. The measurements are performed in the dielectron decay channel, as a function of event centrality and J/$\psi$ transverse momentum $p_{\rm T}$, down to $p_{\rm T}$ = 0 GeV/$c$. The J/$\psi$ mean transverse momentum $\langle p_{\rm T} \rangle$ and $r_{\rm AA}$ ratio, defined as $\langle p^{\rm 2}_{\rm T} \rangle_{\rm PbPb}/\langle p^{\rm 2}_{\rm T} \rangle_{\rm pp}$, are evaluated. Both observables show a centrality dependence decreasing towards central (head-on) collisions. The J/$\psi$ nuclear modification factor $R_{\rm AA}$ exhibits a strong $p_{\rm T}$ dependence with a large suppression at high $p_{\rm T}$ and an increase to unity for decreasing $p_{\rm T}$. When integrating over the measured momentum range $p_{\rm T}$ < 10 GeV/$c$, the J/$\psi$ $R_{\rm AA}$ shows a weak centrality dependence. Each measurement is compared with results at lower center-of-mass energies and with ALICE measurements at forward rapidity, as well as to theory calculations. All reported features of the J/$\psi$ production at low $p_{\rm T}$ are consistent with a dominant contribution to the J/$\psi$ yield originating from charm quark (re)combination.

Measurements of the production of muons from heavy-flavour hadron decays in Pb$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = $5.02$ and $2.76$ TeV using the ALICE detector at the LHC are reported. The nuclear modification factor $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 TeV is measured at forward rapidity ($2.5 < y <4$) as a function of transverse momentum $p_{\rm T}$ in central, semi-central, and peripheral collisions over a wide $p_{\rm T}$ interval, $3 < p_{\rm T} < 20$ GeV/$c$, in which muons from beauty-hadron decays are expected to take over from charm as the dominant source at high $p_{\rm T}$ ($p_{\rm T} > 7$ GeV/$c$). The $R_{\rm AA}$ shows an increase of the suppression of the yields of muons from heavy-flavour hadron decays with increasing centrality. A suppression by a factor of about three is observed in the $10\%$ most central collisions. The $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 is similar to that at 2.76 TeV. The precise $R_{\rm AA}$ measurements have the potential to distinguish between model predictions implementing different mechanisms of parton energy loss in the high-density medium formed in heavy-ion collisions. They place important constraints for the understanding of the heavy-quark interaction with the hot and dense QCD medium.

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark-gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and $pp$ collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadron Collider is presented. The Pb+Pb data were collected in 2015 and 2018 with sampled integrated luminosities of $208~\mathrm{\mu b}^{-1}$ and $38~\mathrm{\mu b^{-1}}$, respectively, and $pp$ data with a sampled integrated luminosity of $1.17~\mathrm{pb}^{-1}$ were collected in 2017. Muons from heavy-flavour semileptonic decays are separated from the light-flavour hadronic background using the momentum imbalance between the inner detector and muon spectrometer measurements, and muons originating from charm and bottom decays are further separated via the muon track's transverse impact parameter. Differential yields in Pb+Pb collisions and differential cross sections in $pp$ collisions for such muons are measured as a function of muon transverse momentum from 4 GeV to 30 GeV in the absolute pseudorapidity interval $|\eta| < 2$. Nuclear modification factors for charm and bottom muons are presented as a function of muon transverse momentum in intervals of Pb+Pb collision centrality. The measured nuclear modification factors quantify a significant suppression of the yields of muons from decays of charm and bottom hadrons, with stronger effects for muons from charm hadron decays.

The $B_\mathrm{c}^+$ meson is observed for the first time in heavy ion collisions. Data from the CMS detector are used to study the production of the $B_\mathrm{c}^+$ meson in lead-lead (PbPb) and proton-proton (pp) collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_{\mathrm{NN}}} =$ 5.02 TeV, via the $B_\mathrm{c}^+ \to (J/\psi\to\mu^+\mu^-)\mu^+\nu_\mu$ decay. The $B_\mathrm{c}^+$ nuclear modification factor, derived from the PbPb-to-pp ratio of production cross sections, is measured in two bins of the trimuon transverse momentum and of the PbPb collision centrality. The B$_\mathrm{c}^+$ meson is shown to be less suppressed than quarkonia and most of the open heavy-flavor mesons, suggesting that effects of the hot and dense nuclear matter created in heavy ion collisions contribute to its production. This measurement sets forth a promising new probe of the interplay of suppression and enhancement mechanisms in the production of heavy-flavor mesons in the quark-gluon plasma.

The production of $\Upsilon$(2S) and $\Upsilon$(3S) mesons in lead-lead (PbPb) and proton-proton (pp) collisions is studied in their dimuon decay channel using the CMS detector at the LHC. The $\Upsilon$(3S) meson is observed for the first time in PbPb collisions, with a significance above five standard deviations. The ratios of yields measured in PbPb and pp collisions are reported for both the $\Upsilon$(2S) and $\Upsilon$(3S) mesons, as functions of transverse momentum and PbPb collision centrality. These ratios, when appropriately scaled, are significantly less than unity, indicating a suppression of $\Upsilon$ yields in PbPb collisions. This suppression increases from peripheral to central PbPb collisions. Furthermore, the suppression is stronger for $\Upsilon$(3S) mesons compared to $\Upsilon$(2S) mesons, extending the pattern of sequential suppression of quarkonium states in nuclear collisions previously seen for the $\psi$/J, $\psi$(2S), $\Upsilon$(1S), and $\Upsilon$(2S) mesons.

This paper presents measurements of charged-hadron spectra obtained in $pp$, $p$+Pb, and Pb+Pb collisions at $\sqrt{s}$ or $\sqrt{s_{_\text{NN}}}=5.02$ TeV, and in Xe+Xe collisions at $\sqrt{s_{_\text{NN}}}=5.44$ TeV. The data recorded by the ATLAS detector at the LHC have total integrated luminosities of 25 pb${}^{-1}$, 28 nb${}^{-1}$, 0.50 nb${}^{-1}$, and 3 $\mu$b${}^{-1}$, respectively. The nuclear modification factors $R_{p\text{Pb}}$ and $R_\text{AA}$ are obtained by comparing the spectra in heavy-ion and $pp$ collisions in a wide range of charged-particle transverse momenta and pseudorapidity. The nuclear modification factor $R_{p\text{Pb}}$ shows a moderate enhancement above unity with a maximum at $p_{\mathrm{T}} \approx 3$ GeV; the enhancement is stronger in the Pb-going direction. The nuclear modification factors in both Pb+Pb and Xe+Xe collisions feature a significant, centrality-dependent suppression. They show a similar distinct $p_{\mathrm{T}}$-dependence with a local maximum at $p_{\mathrm{T}} \approx 2$ GeV and a local minimum at $p_{\mathrm{T}} \approx 7$ GeV. This dependence is more distinguishable in more central collisions. No significant $|\eta|$-dependence is found. A comprehensive comparison with several theoretical predictions is also provided. They typically describe $R_\text{AA}$ better in central collisions and in the $p_{\mathrm{T}}$ range from about 10 to 100 GeV.

The production of prompt $\Lambda^+_\mathrm{c}$ baryons is measured via the exclusive decay channel $\Lambda^+_\mathrm{c}$$\to$ pK$^-\pi^+$ at a center-of-mass energy per nucleon pair of 5.02 TeV, using proton-proton (pp) and lead-lead (PbPb) collision data collected by the CMS experiment at the CERN LHC. The pp and PbPb data were obtained in 2017 and 2018 with integrated luminosities of 252 and 0.607 nb$^{-1}$, respectively. The measurements are performed within the $\Lambda^+_\mathrm{c}$ rapidity interval $\vert y \vert$$\lt$ 1 with transverse momentum ($p_\mathrm{T}$) ranges of 3-30 and 6-40 GeV/$c$ for pp and PbPb collisions, respectively. Compared to the yields in pp collisions scaled by the expected number of nucleon-nucleon interactions, the observed yields of $\Lambda^+_\mathrm{c}$ with $p_\mathrm{T}$$\gt$ 10 GeV/$c$ are strongly suppressed in PbPb collisions. The level of suppression depends significantly on the collision centrality. The $\Lambda^+_\mathrm{c}$ / D$^0$ production ratio is similar in PbPb and pp collisions at $p_\mathrm{T}$$\gt$ 10 GeV/$c$, suggesting that the coalescence process does not play a dominant role in prompt $\Lambda^+_\mathrm{c}$ baryon production at higher $p_\mathrm{T}$.