This paper presents measurements of charged-hadron spectra obtained in $pp$, $p$+Pb, and Pb+Pb collisions at $\sqrt{s}$ or $\sqrt{s_{_\text{NN}}}=5.02$ TeV, and in Xe+Xe collisions at $\sqrt{s_{_\text{NN}}}=5.44$ TeV. The data recorded by the ATLAS detector at the LHC have total integrated luminosities of 25 pb${}^{-1}$, 28 nb${}^{-1}$, 0.50 nb${}^{-1}$, and 3 $\mu$b${}^{-1}$, respectively. The nuclear modification factors $R_{p\text{Pb}}$ and $R_\text{AA}$ are obtained by comparing the spectra in heavy-ion and $pp$ collisions in a wide range of charged-particle transverse momenta and pseudorapidity. The nuclear modification factor $R_{p\text{Pb}}$ shows a moderate enhancement above unity with a maximum at $p_{\mathrm{T}} \approx 3$ GeV; the enhancement is stronger in the Pb-going direction. The nuclear modification factors in both Pb+Pb and Xe+Xe collisions feature a significant, centrality-dependent suppression. They show a similar distinct $p_{\mathrm{T}}$-dependence with a local maximum at $p_{\mathrm{T}} \approx 2$ GeV and a local minimum at $p_{\mathrm{T}} \approx 7$ GeV. This dependence is more distinguishable in more central collisions. No significant $|\eta|$-dependence is found. A comprehensive comparison with several theoretical predictions is also provided. They typically describe $R_\text{AA}$ better in central collisions and in the $p_{\mathrm{T}}$ range from about 10 to 100 GeV.

A measurement of $J/\psi$ and $\psi(2\mathrm{S})$ production is presented. It is based on a data sample from Pb+Pb collisions at $\sqrt{s_{\mathrm{NN}}}$ = 5.02 TeV and $pp$ collisions at $\sqrt{s}$ = 5.02 TeV recorded by the ATLAS detector at the LHC in 2015, corresponding to an integrated luminosity of $0.42\mathrm{nb}^{-1}$ and $25\mathrm{pb}^{-1}$ in Pb+Pb and $pp$, respectively. The measurements of per-event yields, nuclear modification factors, and non-prompt fractions are performed in the dimuon decay channel for $9 < p_{T}^{\mu\mu} < 40$ GeV in dimuon transverse momentum, and $-2.0 < y_{\mu\mu} < 2.0$ in rapidity. Strong suppression is found in Pb+Pb collisions for both prompt and non-prompt $J/\psi$, as well as for prompt and non-prompt $\psi(2\mathrm{S})$, increasing with event centrality. The suppression of prompt $\psi(2\mathrm{S})$ is observed to be stronger than that of $J/\psi$, while the suppression of non-prompt $\psi(2\mathrm{S})$ is equal to that of the non-prompt $J/\psi$ within uncertainties, consistent with the expectation that both arise from \textit{b}-quarks propagating through the medium. Despite prompt and non-prompt $J/\psi$ arising from different mechanisms, the dependence of their nuclear modification factors on centrality is found to be quite similar.

Measurements of the yield and nuclear modification factor, $R_\mathrm{ AA}$, for inclusive jet production are performed using 0.49 nb$^{-1}$ of Pb+Pb data at $\sqrt{s_\mathrm{NN}} = 5.02$ TeV and 25 pb$^{-1}$ of $pp$ data at $\sqrt{s}=5.02$ TeV with the ATLAS detector at the LHC. Jets are reconstructed with the anti-$k_t$ algorithm with radius parameter $R=0.4$ and are measured over the transverse momentum range of 40-1000 GeV in six rapidity intervals covering $|y|<2.8$. The magnitude of $R_\mathrm{ AA}$ increases with increasing jet transverse momentum, reaching a value of approximately 0.6 at 1 TeV in the most central collisions. The magnitude of $R_\mathrm{ AA}$ also increases towards peripheral collisions. The value of $R_\mathrm{ AA}$ is independent of rapidity at low jet transverse momenta, but it is observed to decrease with increasing rapidity at high transverse momenta.

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark-gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and $pp$ collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadron Collider is presented. The Pb+Pb data were collected in 2015 and 2018 with sampled integrated luminosities of $208~\mathrm{\mu b}^{-1}$ and $38~\mathrm{\mu b^{-1}}$, respectively, and $pp$ data with a sampled integrated luminosity of $1.17~\mathrm{pb}^{-1}$ were collected in 2017. Muons from heavy-flavour semileptonic decays are separated from the light-flavour hadronic background using the momentum imbalance between the inner detector and muon spectrometer measurements, and muons originating from charm and bottom decays are further separated via the muon track's transverse impact parameter. Differential yields in Pb+Pb collisions and differential cross sections in $pp$ collisions for such muons are measured as a function of muon transverse momentum from 4 GeV to 30 GeV in the absolute pseudorapidity interval $|\eta| < 2$. Nuclear modification factors for charm and bottom muons are presented as a function of muon transverse momentum in intervals of Pb+Pb collision centrality. The measured nuclear modification factors quantify a significant suppression of the yields of muons from decays of charm and bottom hadrons, with stronger effects for muons from charm hadron decays.

Measurements of inclusive jet production are performed in $pp$ and Pb+Pb collisions at $\sqrt{s_{\mathrm{NN}}}=2.76$ TeV with the ATLAS detector at the LHC, corresponding to integrated luminosities of 4.0 $\mathrm{pb}^{-1}$ and 0.14 $\mathrm{nb}^{-1}$, respectively. The jets are identified with the anti-$k_t$ algorithm with $R=0.4$, and the spectra are measured over the kinematic range of jet transverse momentum $32 < p_{\mathrm{T}} < 500$ GeV, and absolute rapidity $|y| < 2.1$ and as a function of collision centrality. The nuclear modification factor, $R_{\mathrm{AA}}$, is evaluated and jets are found to be suppressed by approximately a factor of two in central collisions compared to $pp$ collisions. The $R_{\mathrm{AA}}$ shows a slight increase with $p_{\mathrm{T}}$ and no significant variation with rapidity.

Charged-particle spectra obtained in 0.15 nb${}^{-1}$ of Pb+Pb interactions at $\sqrt{{s}_\mathsf{{NN}}}=2.76$TeV and 4.2 pb${}^{-1}$ of pp interactions at $\sqrt{s}=2.76$ TeV with the ATLAS detector at the LHC are presented in a wide transverse momentum ($0.5 < p_{\mathrm{T}} < 150$ GeV) and pseudorapidity ($|\eta|<2$) range. For Pb+Pb collisions, the spectra are presented as a function of collision centrality, which is determined by the response of the forward calorimeter located on both sides of the interaction point. The nuclear modification factors $R_{\mathrm{AA}}$ and $R_{\mathrm{CP}}$ are presented in detail as function of centrality, $p_{\mathrm{T}}$ and $\eta$. They show a distinct $p_{\mathrm{T}}$-dependence with a pronounced minimum at about 7 GeV. Above 60 GeV, $R_{\mathrm{AA}}$ is consistent with a plateau at a centrality-dependent value, within the uncertainties. The value is $0.55\pm0.01(stat.)\pm0.04(syst.)$ in the most central collisions. The $R_{\mathrm{AA}}$ distribution is consistent with flat $|\eta|$ dependence over the whole transverse momentum range in all centrality classes.

Parton energy loss in the quark-gluon plasma (QGP) is studied with a measurement of photon-tagged jet production in 1.7 nb$^{-1}$ of Pb+Pb data and 260 pb$^{-1}$ of $pp$ data, both at $\sqrt{s_\mathrm{NN}} = 5.02$ TeV, with the ATLAS detector. The process $pp \to \gamma$+jet+$X$ and its analogue in Pb+Pb collisions is measured in events containing an isolated photon with transverse momentum ($p_\mathrm{T}$) above $50$ GeV and reported as a function of jet $p_\mathrm{T}$. This selection results in a sample of jets with a steeply falling $p_\mathrm{T}$ distribution that are mostly initiated by the showering of quarks. The $pp$ and Pb+Pb measurements are used to report the nuclear modification factor, $R_\mathrm{AA}$, and the fractional energy loss, $S_\mathrm{loss}$, for photon-tagged jets. In addition, the results are compared with the analogous ones for inclusive jets, which have a significantly smaller quark-initiated fraction. The $R_\mathrm{AA}$ and $S_\mathrm{loss}$ values are found to be significantly different between those for photon-tagged jets and inclusive jets, demonstrating that energy loss in the QGP is sensitive to the colour-charge of the initiating parton. The results are also compared with a variety of theoretical models of colour-charge-dependent energy loss.

Electrons from heavy-flavour hadron decays (charm and beauty) were measured with the ALICE detector in Pb-Pb collisions at a centre-of-mass of energy $\sqrt{s_{\rm NN}}=2.76$ TeV. The transverse momentum ($p_{\rm T}$) differential production yields at mid-rapidity were used to calculate the nuclear modification factor $R_{\rm AA}$ in the interval $3<p_{\rm T}< 18$ GeV/$c$. The $R_{\rm AA}$ shows a strong suppression compared to binary scaling of pp collisions at the same energy (up to a factor of 4) in the 10% most central Pb-Pb collisions. There is a centrality trend of suppression, and a weaker suppression (down to a factor of 2) in semi-peripheral (50-80%) collisions is observed. The suppression of electrons in this broad $p_{\rm T}$ interval indicates that both charm and beauty quarks lose energy when they traverse the hot medium formed in Pb-Pb collisions at LHC.

The production of J/$\psi$ and $\psi(2S)$ was measured with the ALICE detector in Pb-Pb collisions at the LHC. The measurement was performed at forward rapidity ($2.5 < y < 4 $) down to zero transverse momentum ($p_{\rm T}$) in the dimuon decay channel. Inclusive J/$\psi$ yields were extracted in different centrality classes and the centrality dependence of the average $p_{\rm T}$ is presented. The J/$\psi$ suppression, quantified with the nuclear modification factor ($R_{\rm AA}$), was studied as a function of centrality, transverse momentum and rapidity. Comparisons with similar measurements at lower collision energy and theoretical models indicate that the J/$\psi$ production is the result of an interplay between color screening and recombination mechanisms in a deconfined partonic medium, or at its hadronization. Results on the $\psi(2S)$ suppression are provided via the ratio of $\psi(2S)$ over J/$\psi$ measured in pp and Pb-Pb collisions.

Measurements of the production of muons from heavy-flavour hadron decays in Pb$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = $5.02$ and $2.76$ TeV using the ALICE detector at the LHC are reported. The nuclear modification factor $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 TeV is measured at forward rapidity ($2.5 < y <4$) as a function of transverse momentum $p_{\rm T}$ in central, semi-central, and peripheral collisions over a wide $p_{\rm T}$ interval, $3 < p_{\rm T} < 20$ GeV/$c$, in which muons from beauty-hadron decays are expected to take over from charm as the dominant source at high $p_{\rm T}$ ($p_{\rm T} > 7$ GeV/$c$). The $R_{\rm AA}$ shows an increase of the suppression of the yields of muons from heavy-flavour hadron decays with increasing centrality. A suppression by a factor of about three is observed in the $10\%$ most central collisions. The $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 is similar to that at 2.76 TeV. The precise $R_{\rm AA}$ measurements have the potential to distinguish between model predictions implementing different mechanisms of parton energy loss in the high-density medium formed in heavy-ion collisions. They place important constraints for the understanding of the heavy-quark interaction with the hot and dense QCD medium.