Nuclear medium effects on B$^+$ meson production are studied using the binary-collision scaled cross section ratio between events of different charged-particle multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of $\sqrt{s_\mathrm{NN}}$ = 8.16 TeV, corresponding to an integrated luminosity of 175 nb$^{-1}$, were used. The scaling factors in the ratio are determined using a novel approach based on the Z $\to$$\mu^+\mu^-$ cross sections measured in the same events. The scaled ratio for B$^+$ is consistent with unity for all event multiplicities, putting stringent constraints on nuclear modification for heavy flavor.
Production cross sections of $\Upsilon$(1S), $\Upsilon$(2S), and $\Upsilon$(3S) states decaying into $\mu^+\mu^-$ in proton-lead (pPb) collisions are reported using data collected by the CMS experiment at $\sqrt{s_\mathrm{NN}} =$ 5.02 TeV. A comparison is made with corresponding cross sections obtained with pp data measured at the same collision energy and scaled by the Pb nucleus mass number. The nuclear modification factor for $\Upsilon$(1S) is found to be $R_\mathrm{pPb}(\Upsilon(1S))$ = 0.806 $\pm$ 0.024 (stat) $\pm$ 0.059 (syst). Similar results for the excited states indicate a sequential suppression pattern, such that $R_\mathrm{pPb}(\Upsilon(1S))$$\gt$$R_\mathrm{pPb}(\Upsilon(2S))$$\gt$$R_\mathrm{pPb}(\Upsilon(3S))$. The suppression is much less pronounced in pPb than in PbPb collisions, and independent of transverse momentum $p_\mathrm{T}^\Upsilon$ and center-of-mass rapidity $y_\mathrm{CM}^\Upsilon$ of the individual $\Upsilon$ state in the studied range $p_\mathrm{T}^\Upsilon$$\lt$ 30 GeV$/c$ and $\vert y_\mathrm{CM}^\Upsilon\vert$$\lt$ 1.93. Models that incorporate sequential suppression of bottomonia in pPb collisions are in better agreement with the data than those which only assume initial-state modifications.
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