This paper presents the observation of four-top-quark ($t\bar{t}t\bar{t}$) production in proton-proton collisions at the LHC. The analysis is performed using an integrated luminosity of 140 fb$^{-1}$ at a centre-of-mass energy of 13 TeV collected using the ATLAS detector. Events containing two leptons with the same electric charge or at least three leptons (electrons or muons) are selected. Event kinematics are used to separate signal from background through a multivariate discriminant, and dedicated control regions are used to constrain the dominant backgrounds. The observed (expected) significance of the measured $t\bar{t}t\bar{t}$ signal with respect to the standard model (SM) background-only hypothesis is 6.1 (4.3) standard deviations. The $t\bar{t}t\bar{t}$ production cross section is measured to be $22.5^{+6.6}_{-5.5}$ fb, consistent with the SM prediction of $12.0 \pm 2.4$ fb within 1.8 standard deviations. Data are also used to set limits on the three-top-quark production cross section, being an irreducible background not measured previously, and to constrain the top-Higgs Yukawa coupling and effective field theory operator coefficients that affect $t\bar{t}t\bar{t}$ production.
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb$^{-1}$ is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain $b$-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26$^{+17}_{-15}$ fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24$^{+7}_{-6}$ fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0$\pm$2.4 fb.
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