Proton-proton interactions resulting in final states with two photons are studied in a search for the signature of flavor-changing neutral current interactions of top quarks (t) and Higgs bosons (H). The analysis is based on data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 137 fb$^{-1}$. No significant excess above the background prediction is observed. Upper limits on the branching fractions ($\mathcal{B}$) of the top quark decaying to a Higgs boson and an up (u) or charm quark (c) are derived through a binned fit to the diphoton invariant mass spectrum. The observed (expected) 95% confidence level upper limits are found to be 0.019 (0.031)% for $\mathcal B$(t $\to$ Hu) and 0.073 (0.051)% for $\mathcal{B}$(t $\to$ Hc). These are the strictest upper limits yet determined.

A search for low-mass dilepton resonances in Higgs boson decays is conducted in the four-lepton final state. The decay is assumed to proceed via a pair of beyond the standard model particles, or one such particle and a Z boson. The search uses proton-proton collision data collected with the CMS detector at the CERN LHC, corresponding to an integrated luminosity of 137 fb$^{-1}$, at a center-of-mass energy $\sqrt{s} =$ 13 TeV. No significant deviation from the standard model expectation is observed. Upper limits at 95% confidence level are set on model-independent Higgs boson decay branching fractions. Additionally, limits on dark photon and axion-like particle production, based on two specific models, are reported.

A search is presented for long-lived particles produced in pairs in proton-proton collisions at the LHC operating at a center-of-mass energy of 13 TeV. The data were collected with the CMS detector during the period from 2015 through 2018, and correspond to a total integrated luminosity of 140 fb$^{-1}$. This search targets pairs of long-lived particles with mean proper decay lengths between 0.1 and 100 mm, each of which decays into at least two quarks that hadronize to jets, resulting in a final state with two displaced vertices. No significant excess of events with two displaced vertices is observed. In the context of $R$-parity violating supersymmetry models, the pair production of long-lived neutralinos, gluinos, and top squarks is excluded at 95% confidence level for cross sections larger than 0.08 fb, masses between 800 and 3000 GeV, and mean proper decay lengths between 1 and 25 mm.

A search for physics beyond the standard model (SM) in the final state with a hadronically decaying tau lepton and a neutrino is presented. This analysis is based on data recorded by the CMS experiment from proton-proton collisions at a center-of-mass energy of 13 TeV at the LHC, corresponding to a total integrated luminosity of 138 fb$^{=1}$. The transverse mass spectrum is analyzed for the presence of new physics. No significant deviation from the SM prediction is observed. Limits are set on the production cross section of a W' boson decaying into a tau lepton and a neutrino. Lower limits are set on the mass of the sequential SM-like heavy charged vector boson and the mass of a quantum black hole. Upper limits are placed on the couplings of a new boson to the SM fermions. Constraints are put on a nonuniversal gauge interaction model and an effective field theory model. For the first time, upper limits on the cross section of $t$-channel leptoquark (LQ) exchange are presented. These limits are translated into exclusion limits on the LQ mass and on its coupling in the $t$-channel. The sensitivity of this analysis extends into the parameter space of LQ models that attempt to explain the anomalies observed in B meson decays. The limits presented for the various interpretations are the most stringent to date. Additionally, a model-independent limit is provided.

A search for a heavy resonance decaying into a top quark and a W boson in proton-proton collisions at $\sqrt{s} =$ 13 TeV is presented. The data analyzed were recorded with the CMS detector at the LHC and correspond to an integrated luminosity of 138 fb$^{-1}$. The top quark is reconstructed as a single jet and the W boson, from its decay into an electron or muon and the corresponding neutrino. A top quark tagging technique based on jet clustering with a variable distance parameter and simultaneous jet grooming is used to identify jets from the collimated top quark decay. The results are interpreted in the context of two benchmark models, where the heavy resonance is either an excited bottom quark b$^*$ or a vector-like quark B. A statistical combination with an earlier search by the CMS Collaboration in the all-hadronic final state is performed to place upper cross section limits on these two models. The new analysis extends the lower range of resonance mass probed from 1.4 down to 0.7 TeV. For left-handed, right-handed, and vector-like couplings, b$^*$ masses up to 3.0, 3.0, and 3.2 TeV are excluded at 95% confidence level, respectively. The observed upper limits represent the most stringent constraints on the b$^*$ model to date.

A combination of measurements of the inclusive top-quark pair production cross-section performed by ATLAS and CMS in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV at the LHC is presented. The cross-sections are obtained using top-quark pair decays with an opposite-charge electron-muon pair in the final state and with data corresponding to an integrated luminosity of about 5 fb$^{-1}$ at $\sqrt{s}=7$ TeV and about 20 fb$^{-1}$ at $\sqrt{s}=8$ TeV for each experiment. The combined cross-sections are determined to be $178.5 \pm 4.7$ pb at $\sqrt{s}=7$ TeV and $243.3^{+6.0}_{-5.9}$ pb at $\sqrt{s}=8$ TeV with a correlation of 0.41, using a reference top-quark mass value of 172.5 GeV. The ratio of the combined cross-sections is determined to be $R_{8/7}= 1.363\pm 0.032$. The combined measured cross-sections and their ratio agree well with theory calculations using several parton distribution function (PDF) sets. The values of the top-quark pole mass (with the strong coupling fixed at 0.118) and the strong coupling (with the top-quark pole mass fixed at 172.5 GeV) are extracted from the combined results by fitting a next-to-next-to-leading-order plus next-to-next-to-leading-log QCD prediction to the measurements. Using a version of the NNPDF3.1 PDF set containing no top-quark measurements, the results obtained are $m_t^\text{pole} = 173.4^{+1.8}_{-2.0}$ GeV and $\alpha_\text{s}(m_Z)= 0.1170^{+ 0.0021}_{-0.0018}$.

Pseudorapidity (eta) distributions of charged particles produced in proton-proton collisions at a centre-of-mass energy of 8 TeV are measured in the ranges abs(eta) < 2.2 and 5.3 < abs(eta) < 6.4 covered by the CMS and TOTEM detectors, respectively. The data correspond to an integrated luminosity of 45 inverse microbarns. Measurements are presented for three event categories. The most inclusive category is sensitive to 91-96% of the total inelastic proton-proton cross section. The other two categories are disjoint subsets of the inclusive sample that are either enhanced or depleted in single diffractive dissociation events. The data are compared to models used to describe high-energy hadronic interactions. None of the models considered provide a consistent description of the measured distributions.

Quasireal photons exchanged in relativistic heavy ion interactions are powerful probes of the gluonic structure of nuclei. The coherent J/$\psi$ photoproduction cross section in ultraperipheral lead-lead collisions is measured as a function of photon-nucleus center-of-mass energies per nucleon (W$^\text{Pb}_{\gamma\text{N}}$), over a wide range of 40 $\lt$ W$^\text{Pb}_{\gamma\text{N}}$$\lt$ 400 GeV. Results are obtained using data at the nucleon-nucleon center-of-mass energy of 5.02 TeV collected by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of 1.52 nb$^{-1}$. The cross section is observed to rise rapidly at low W$^\text{Pb}_{\gamma\text{N}}$, and plateau above W$^\text{Pb}_{\gamma\text{N}}$$\approx$ 40 GeV, up to 400 GeV, a new regime of small Bjorken-$x$ ($\approx$ 6 $\times$ 10$^{-5}$) gluons being probed in a heavy nucleus. The observed energy dependence is not predicted by current quantum chromodynamic models.

A search for physics beyond the standard model in events with at least three charged leptons (electrons or muons) is presented. The data sample corresponds to an integrated luminosity of 137 fb$^{-1}$ of proton-proton collisions at $\sqrt{s} =$ 13 TeV, collected with the CMS detector at the LHC in 2016-2018. The two targeted signal processes are pair production of type-III seesaw heavy fermions and production of a light scalar or pseudoscalar boson in association with a pair of top quarks. The heavy fermions may be manifested as an excess of events with large values of leptonic transverse momenta or missing transverse momentum. The light scalars or pseudoscalars may create a localized excess in the dilepton mass spectra. The results exclude heavy fermions of the type-III seesaw model for masses below 880 GeV at 95% confidence level in the scenario of equal branching fractions to each lepton flavor. This is the most restrictive limit on the flavor-democratic scenario of the type-III seesaw model to date. Assuming a Yukawa coupling of unit strength to top quarks, branching fractions of new scalar (pseudoscalar) bosons to dielectrons or dimuons above 0.004 (0.03) and 0.04 (0.03) are excluded at 95% confidence level for masses in the range 15-75 and 108-340 GeV, respectively. These are the first limits in these channels on an extension of the standard model with scalar or pseudoscalar particles.

A search for narrow and broad resonances with masses greater than 1.8 TeV decaying to a pair of jets is presented. The search uses proton-proton collision data at $\sqrt{s} =$ 13 TeV collected at the LHC, corresponding to an integrated luminosity of 137 fb$^{-1}$. The background arising from standard model processes is predicted with the fit method used in previous publications and with a new method. The dijet invariant mass spectrum is well described by both data-driven methods, and no significant evidence for the production of new particles is observed. Model independent upper limits are reported on the production cross sections of narrow resonances, and broad resonances with widths up to 55% of the resonance mass. Limits are presented on the masses of narrow resonances from various models: string resonances, scalar diquarks, axigluons, colorons, excited quarks, color-octet scalars, W' and Z' bosons, Randall-Sundrum gravitons, and dark matter mediators. The limits on narrow resonances are improved by 200 to 800 GeV relative to those reported in previous CMS dijet resonance searches. The limits on dark matter mediators are presented as a function of the resonance mass and width, and on the associated coupling strength as a function of the mediator mass. These limits exclude at 95% confidence level a dark matter mediator with a mass of 1.8 TeV and width 1% of its mass or higher, up to one with a mass of 4.8 TeV and a width 45% of its mass or higher.

Signals consistent with the B$^+_\mathrm{c}$(2S) and B$^{*+}_\mathrm{c}$(2S) states are observed in proton-proton collisions at $\sqrt{s} =$ 13 TeV, in an event sample corresponding to an integrated luminosity of 140 fb$^{-1}$, collected by the CMS experiment during the 2016, 2017, and 2018 LHC running periods. These excited $\bar{\mathrm{b}}$c states are observed in the B$^+_\mathrm{c}\pi^+\pi^-$ invariant mass spectrum, with the ground state B$^+_\mathrm{c}$ reconstructed through its decay to J/$\psi\,\pi^+$. The two states are well resolved from each other and are observed with a significance exceeding five standard deviations. The mass of the B$^+_\mathrm{c}$(2S) meson is measured to be 6871.0 $\pm$ 1.2 (stat) $\pm$ 0.8 (syst) $\pm$ 0.8 (B$^+_\mathrm{c}$) MeV, where the last term corresponds to the uncertainty in the world-average B$^+_\mathrm{c}$ mass.

A search for a narrow resonance with a mass between 350 and 700 GeV, and decaying into a pair of jets, is performed using proton-proton collision events containing at least three jets. The data sample corresponds to an integrated luminosity of 18.3 fb$^{-1}$ recorded at $\sqrt{s} =$ 13 TeV with the CMS detector. Data are collected with a technique known as "data scouting", in which the events are reconstructed, selected, and recorded at a high rate in a compact form by the high-level trigger. The three-jet final state provides sensitivity to lower resonance masses than in previous searches using the data scouting technique. The spectrum of the dijet invariant mass, calculated from the two jets with the largest transverse momenta in the event, is used to search for a resonance. No significant excess over a smoothly falling background is found. Limits at 95% confidence level are set on the production cross section of a narrow dijet resonance and compared with the cross section of a vector dark matter mediator coupling to dark matter particles and quarks. Translating to a model where the narrow vector resonance interacts only with quarks, upper limits on this coupling range between 0.10 and 0.15, depending on the resonance mass. These results represent the most stringent upper limits in the mass range between 350 and 450 GeV obtained with a flavor-inclusive dijet resonance search.

A search is presented for a narrow resonance decaying to a pair of oppositely charged muons using $\sqrt{s} =$ 13 TeV proton-proton collision data recorded at the LHC. In the 45-75 and 110-200 GeV resonance mass ranges, the search is based on conventional triggering and event reconstruction techniques. In the 11.5-45 GeV mass range, the search uses data collected with dimuon triggers with low transverse momentum thresholds, recorded at high rate by storing a reduced amount of trigger-level information. The data correspond to integrated luminosities of 137 fb$^{-1}$ and 96.6 fb$^{-1}$ for conventional and high-rate triggering, respectively. No significant resonant peaks are observed in the probed mass ranges. The search sets the most stringent constraints to date on a dark photon in the $\sim$30-75 and 110-200 GeV mass ranges.

Measurements of differential and double-differential cross sections of top quark pair ($\text{t}\overline{\text{t}}$) production are presented in the lepton+jets channels with a single electron or muon and jets in the final state. The analysis combines for the first time signatures of top quarks with low transverse momentum $p_\text{T}$, where the top quark decay products can be identified as separated jets and isolated leptons, and with high $p_\text{T}$, where the decay products are collimated and overlap. The measurements are based on proton-proton collision data at $\sqrt{s} = $ 13 TeV collected by the CMS experiment at the LHC, corresponding to an integrated luminosity of 137 fb$^{-1}$. The cross sections are presented at the parton and particle levels, where the latter minimizes extrapolations based on theoretical assumptions. Most of the measured differential cross sections are well described by standard model predictions with the exception of some double-differential distributions. The inclusive $\text{t}\overline{\text{t}}$ production cross section is measured to be $\sigma_{\text{t}\overline{\text{t}}} = $ 791 $\pm$ 25 pb, which constitutes the most precise measurement in the lepton+jets channel to date.

The first measurements of diboson production cross sections in proton-proton interactions at a center-of-mass energy of 5.02 TeV are reported. They are based on data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 302 pb$^{-1}$. Events with two, three, or four charged light leptons (electrons or muons) in the final state are analyzed. The WW, WZ, and ZZ total cross sections are measured as $\sigma_\mathrm{WW} =$ 37.0 $^{+5.5}_{-5.2}$ (stat) $^{+2.7}_{-2.6}$ (syst) pb, $\sigma_\mathrm{WZ} =$ 6.4 $^{+2.5}_{-2.1}$ (stat) $^{+0.5}_{-0.3}$ (syst) pb, and $\sigma_\mathrm{ZZ} =$ 5.3 $^{+2.5}_{-2.1}$ (stat) $^{+0.5}_{-0.4}$ (syst) pb. All measurements are in good agreement with theoretical calculations at combined next-to-next-to-leading order quantum chromodynamics and next-to-leading order electroweak accuracy.

The first observation of the electroweak (EW) production of a Z boson, a photon, and two forward jets (Z$\gamma$jj) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented. A data set corresponding to an integrated luminosity of 137 fb$^{-1}$, collected by the CMS experiment at the LHC in 2016-2018 is used. The measured fiducial cross section for EW Z$\gamma$jj is $\sigma_{\mathrm{EW}}$ = 5.21 $\pm$ 0.52 (stat) $\pm$ 0.56 (syst) fb = 5.21 $\pm$ 0.76 fb. Single-differential cross sections in photon, leading lepton, and leading jet transverse momenta, and double-differential cross sections in $m_{\mathrm{jj}}$ and $\lvert\Delta\eta_{\mathrm{jj}}\rvert$ are also measured. Exclusion limits on anomalous quartic gauge couplings are derived at 95% confidence level in terms of the effective field theory operators $\mathrm{M}_{0}$ to $\mathrm{M}_{5}$, $\mathrm{M}_{7}$, $\mathrm{T}_{0}$ to $\mathrm{T}_{2}$, and $\mathrm{T}_{5}$ to $\mathrm{T}_{9}$.

A search for a heavy Higgs boson H decaying into the observed Higgs boson h with a mass of 125 GeV and another Higgs boson h$_\mathrm{S}$ is presented. The h and h$_\mathrm{S}$ bosons are required to decay into a pair of tau leptons and a pair of b quarks, respectively. The search uses a sample of proton-proton collisions collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 137 fb$^{-1}$. Mass ranges of 240-3000 GeV for $m_\mathrm{H}$ and 60-2800 GeV for $m_\mathrm{h_S}$ are explored in the search. No signal has been observed. Model independent 95% confidence level upper limits on the product of the production cross section and the branching fractions of the signal process are set with a sensitivity ranging from 125 fb (for $m_\mathrm{H}$ $=$ 240 GeV) to 2.7 fb (for $m_\mathrm{H}$ $=$ 1000 GeV). These limits are compared to maximally allowed products of the production cross section and the branching fractions of the signal process in the next-to-minimal supersymmetric extension of the standard model.

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb$^{-1}$ collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on the model, the combined result excludes a top squark mass up to 1325 GeV for a massless neutralino, and a neutralino mass up to 700 GeV for a top squark mass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV.

A measurement of the top quark mass is performed using a data sample enriched with single top quark events produced in the $t$ channel. The study is based on proton-proton collision data, corresponding to an integrated luminosity of 35.9 fb$^{-1}$, recorded at $\sqrt{s}$ = 13 TeV by the CMS experiment at the LHC in 2016. Candidate events are selected by requiring an isolated high-momentum lepton (muon or electron) and exactly two jets, of which one is identified as originating from a bottom quark. Multivariate discriminants are designed to separate the signal from the background. Optimized thresholds are placed on the discriminant outputs to obtain an event sample with high signal purity. The top quark mass is found to be 172.13 $^{+0.76}_{-0.77}$ GeV, where the uncertainty includes both the statistical and systematic components, reaching sub-GeV precision for the first time in this event topology. The masses of the top quark and antiquark are also determined separately using the lepton charge in the final state, from which the mass ratio and difference are determined to be 0.9952 $^{+0.0079}_{-0.0104}$ and 0.83 $^{+1.79}_{-1.35}$ GeV, respectively. The results are consistent with $CPT$ invariance.

Bose-Einstein correlations between identical particles are measured in samples of proton-proton collisions at 0.9 and 7 TeV centre-of-mass energies, recorded by the CMS experiment at the LHC. The signal is observed in the form of an enhancement of number of pairs of same-sign charged particles with small relative momentum. The dependence of this enhancement on kinematic and topological features of the event is studied.

A measurement is presented of electroweak (EW) production of a W boson in association with two jets in proton-proton collisions at $\sqrt{s} =$ 13 TeV. The data sample was recorded by the CMS Collaboration at the LHC and corresponds to an integrated luminosity of 35.9 fb$^{-1}$. The measurement is performed for the $\ell\nu$jj final state (with $\ell\nu$ indicating a lepton-neutrino pair, and j representing the quarks produced in the hard interaction) in a kinematic region defined by invariant mass $m_\mathrm{jj}$ $>$ 120 GeV and transverse momenta $p_\mathrm{T j}$ $>$ 25 GeV. The cross section of the process is measured in the electron and muon channels yielding $\sigma_\mathrm{EW}$(Wjj) = 6.23 $\pm$ 0.12 (stat) $\pm$ 0.61 (syst) pb per channel, in agreement with leading-order standard model predictions. The additional hadronic activity of events in a signal-enriched region is studied, and the measurements are compared with predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. Limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are $-$2.3 $<$ $c_{\mathrm{WWW}}/\Lambda^2$ $<$ 2.5 TeV$^{-2}$, $-$8.8 $<$ $c_{\mathrm{W}}/\Lambda^2$ $<$ 16 TeV$^{-2}$, and $-$45 $<$ $c_{\mathrm{B}}/\Lambda^2$ $<$ 46 TeV$^{-2}$. These results are combined with the CMS EW Zjj analysis, yielding the constraint on the $c_{\mathrm{WWW}}$ coupling: $-$1.8 $<$ $c_{\mathrm{WWW}}/\Lambda^2$ $<$ 2.0 TeV$^{-2}$.

A search for anomalous electroweak production of WW, WZ, and ZZ boson pairs in association with two jets in proton-proton collisions at $\sqrt{s} =$ 13 TeV at the LHC is reported. The data sample corresponds to an integrated luminosity of 35.9 fb$^{-1}$ collected with the CMS detector. Events are selected by requiring two jets with large rapidity separation and invariant mass, one or two leptons (electrons or muons), and a W or Z boson decaying hadronically. No excess of events with respect to the standard model background predictions is observed and constraints on the structure of quartic vector boson interactions in the framework of dimension-8 effective field theory operators are reported. Stringent limits on parameters of the effective field theory operators are obtained. The observed 95% confidence level limits for the S0, M0, and T0 operators are $-$2.7 $<$ f$_{\mathrm{S0}}/ \Lambda^{4}$ $<$ 2.7, $-$1.0 $<$ f$_{\mathrm{M0}}/ \Lambda^{4}$ $<$ 1.0, and $-$0.17 $<$ f$_{\mathrm{T0}}/ \Lambda^{4}$ $<$ 0.16, in units of TeV$^{-4}$. Constraints are also reported on the product of the cross section and branching fraction for vector boson fusion production of charged Higgs bosons as a function of mass from 600 to 2000 GeV. The results are interpreted in the context of the Georgi-Machacek model.

A search for the pair production of heavy vector-like partners T and B of the top and bottom quarks has been performed by the CMS experiment at the CERN LHC using proton-proton collisions at $\sqrt{s} =$ 13 TeV. The data sample was collected in 2016 and corresponds to an integrated luminosity of 35.9 fb$^{-1}$. Final states studied for $\mathrm{T\overline{T}}$ production include those where one of the T quarks decays via T $\to$ tZ and the other via T $\to$ bW, tZ, or tH, where H is a Higgs boson. For the $\mathrm{B\overline{B}}$ case, final states include those where one of the B quarks decays via B $\to$ bZ and the other B $\to$ tW, bZ, or bH. Events with two oppositely charged electrons or muons, consistent with coming from the decay of a Z boson, and jets are investigated. The number of observed events is consistent with standard model background estimations. Lower limits at 95% confidence level are placed on the masses of the T and B quarks for a range of branching fractions. Assuming 100% branching fractions for T $\to$ tZ, and B $\to$ bZ, T and B quark mass values below 1280 and 1130 GeV, respectively, are excluded.

Measurements are presented of the triple-differential cross section for inclusive isolated-photon+jet events in pp collisions at $\sqrt{s} =$ 8 TeV as a function of photon transverse momentum ($p_\mathrm{T}^\gamma$), photon pseudorapidity ($\eta^\gamma$), and jet pseudorapidity ($\eta^\text{jet}$). The data correspond to an integrated luminosity of 19.7 fb$^{-1}$ that probe a broad range of the available phase space, for $|\eta^\gamma|$ $<$ 1.44 and 1.57 $<$ $|\eta^\gamma|$ $<$ 2.50, $|\eta^\text{jet}|$ $<$ 2.5, 40 $<$ $p_\mathrm{T}^\gamma$ $<$ 1000 GeV, and jet transverse momentum, $p_\mathrm{T}^\text{jet}$, $>$ 25 GeV. The measurements are compared to next-to-leading order perturbative quantum chromodynamics calculations, which reproduce the data within uncertainties.

A search for supersymmetry is presented based on events with at least one photon, jets, and large missing transverse momentum produced in proton-proton collisions at a center-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 35.9 fb$^{-1}$ and were recorded at the LHC with the CMS detector in 2016. The analysis characterizes signal-like events by categorizing the data into various signal regions based on the number of jets, the number of b-tagged jets, and the missing transverse momentum. No significant excess of events is observed with respect to the expectations from standard model processes. Limits are placed on the gluino and top squark pair production cross sections using several simplified models of supersymmetric particle production with gauge-mediated supersymmetry breaking. Depending on the model and the mass of the next-to-lightest supersymmetric particle, the production of gluinos with masses as large as 2120 GeV and the production of top squarks with masses as large as 1230 GeV are excluded at 95% confidence level.