We report the first observation of the associated production of a W boson and a Z boson. This result is based on 1.1 fb-1 of integrated luminosity from ppbar collisions at sqrt{s} = 1.96 TeV collected with the CDF II detector at the Fermilab Tevatron. We observe 16 WZ candidates passing our event selection with an expected background of 2.7 +/- 0.4 events. A fit to the missing transverse energy distribution indicates an excess of events compared to the background expectation corresponding to a significance equivalent to six standard deviations. The measured cross section is sigma(ppbar -> WZ) = 5.0^{+1.8}_{-1.6} pb, consistent with the standard model expectation.
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