The observation of the production of four top quarks in proton-proton collisions is reported, based on a data sample collected by the CMS experiment at a center-of-mass energy of 13 TeV in 2016-2018 at the CERN LHC and corresponding to an integrated luminosity of 138 fb$^{-1}$. Events with two same-sign, three, or four charged leptons (electrons and muons) and additional jets are analyzed. Compared to previous results in these channels, updated identification techniques for charged leptons and jets originating from the hadronization of b quarks, as well as a revised multivariate analysis strategy to distinguish the signal process from the main backgrounds, lead to an improved expected signal significance of 4.9 standard deviations above the background-only hypothesis. Four top quark production is observed with a significance of 5.6 standard deviations, and its cross section is measured to be 17.7 $^{+3.7}_{-3.5}$ (stat) $^{+2.3}_{-1.9}$ (syst) fb, in agreement with the available standard model predictions.

A measurement is presented of the production of Z bosons that decay into two electrons or muons in association with jets, in proton-proton collisions at a centre-of-mass energy of 13 TeV. The data were recorded by the CMS Collaboration at the LHC with an integrated luminosity of 35.9 fb$^{-1}$. The differential cross sections are measured as a function of the transverse momentum ($p_\mathrm{T}$) of the Z boson and the transverse momentum and rapidities of the five jets with largest $p_\mathrm{T}$. The jet multiplicity distribution is measured for up to eight jets. The hadronic activity in the events is estimated using the scalar sum of the $p_\mathrm{T}$ of all the jets. All measurements are unfolded to the stable particle-level and compared with predictions from various Monte Carlo event generators, as well as with expectations at leading and next-to-leading orders in perturbative quantum chromodynamics.

The results of a search for Higgs boson pair (HH) production in the WW*WW*, WW*$\tau\tau$, and $\tau\tau\tau\tau$ decay modes are presented. The search uses 138 fb$^{-1}$ of proton-proton collision data recorded by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV from 2016 to 2018. Analyzed events contain two, three, or four reconstructed leptons, including electrons, muons, and hadronically decaying tau leptons. No evidence for a signal is found in the data. Upper limits are set on the cross section for nonresonant HH production, as well as resonant production in which a new heavy particle decays to a pair of Higgs bosons. For nonresonant production, the observed (expected) upper limit on the cross section at 95% confidence level (CL) is 21.3 (19.4) times the standard model (SM) prediction. The observed (expected) ratio of the trilinear Higgs boson self-coupling to its value in the SM is constrained to be within the interval $-$6.9 to 11.1 ($-$6.9 to 11.7) at 95% CL, and limits are set on a variety of new-physics models using an effective field theory approach. The observed (expected) limits on the cross section for resonant HH production range from 0.18 to 0.90 (0.08 to 1.06) pb at 95% CL for new heavy-particle masses in the range 250-1000 GeV.

A first observation is presented for the electroweak production of a W boson, a photon, and two jets in proton-proton collisions. The W boson decays are selected by requiring one identified electron or muon and an imbalance in transverse momentum. The two jets are required to have a high dijet mass and a large separation in pseudorapidity. The measurement is based on data collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{-1}$. The observed (expected) significance for this process is 4.9 (4.6) standard deviations. After combining with previously reported CMS results at 8 TeV, the observed (expected) significance is 5.3 (4.8) standard deviations. The cross section for the electroweak W$\gamma$jj production in a restricted fiducial region is measured as 20.4 $\pm$ 4.5 fb and the total cross section for W$\gamma$ production in association with 2 jets in the same fiducial region is 108 $\pm$ 16 fb. All results are in good agreement with recent theoretical predictions. Constraints are placed on anomalous quartic gauge couplings in terms of dimension-8 effective field theory operators.

Evidence is presented for the electroweak (EW) production of two jets (jj) in association with two Z bosons and constraints on anomalous quartic gauge couplings are set. The analysis is based on a data sample of proton-proton collisions at $\sqrt{s} = $ 13 TeV collected with the CMS detector in 2016-2018, and corresponding to an integrated luminosity of 137 fb$^{-1}$. The search is performed in the fully leptonic final state ZZ $\to$ $\ell\ell\ell'\ell'$, where $\ell,\ell' = $ e, $\mu$. The EW production of two jets in association with two Z bosons is measured with an observed (expected) significance of 4.0 (3.5) standard deviations. The cross sections for the EW production are measured in three fiducial volumes and the result is $\sigma_{\mathrm{EW}}$(pp $\to$ ZZjj $\to$ $\ell\ell\ell'\ell'$jj) = 0.33 $^{+0.11}_{-0.10}$ (stat) $^{+0.04}_{-0.03}$ (syst) fb in the most inclusive volume, in agreement with the standard model prediction of 0.275 $\pm$ 0.021 fb. Measurements of total cross sections for jj production in association with two Z bosons are also reported. Limits on anomalous quartic gauge couplings are derived in terms of the effective field theory operators T0, T1, T2, T8, and T9.

A fiducial cross section for W$\gamma$ production in proton-proton collisions is measured at a center-of-mass energy of 13 TeV in 137 fb$^{-1}$ of data collected using the CMS detector at the LHC. The W $\to$ e$\nu$ and $\mu\nu$ decay modes are used in a maximum-likelihood fit to the lepton-photon invariant mass distribution to extract the combined cross section. The measured cross section is compared with theoretical expectations at next-to-leading order in quantum chromodynamics. In addition, 95% confidence level intervals are reported for anomalous triple-gauge couplings within the framework of effective field theory.

Measurements of differential and double-differential cross sections of top quark pair ($\text{t}\overline{\text{t}}$) production are presented in the lepton+jets channels with a single electron or muon and jets in the final state. The analysis combines for the first time signatures of top quarks with low transverse momentum $p_\text{T}$, where the top quark decay products can be identified as separated jets and isolated leptons, and with high $p_\text{T}$, where the decay products are collimated and overlap. The measurements are based on proton-proton collision data at $\sqrt{s} = $ 13 TeV collected by the CMS experiment at the LHC, corresponding to an integrated luminosity of 137 fb$^{-1}$. The cross sections are presented at the parton and particle levels, where the latter minimizes extrapolations based on theoretical assumptions. Most of the measured differential cross sections are well described by standard model predictions with the exception of some double-differential distributions. The inclusive $\text{t}\overline{\text{t}}$ production cross section is measured to be $\sigma_{\text{t}\overline{\text{t}}} = $ 791 $\pm$ 25 pb, which constitutes the most precise measurement in the lepton+jets channel to date.

A measurement of the cross section of the associated production of a single top quark and a W boson in final states with a muon or electron and jets in proton-proton collisions at $\sqrt{s}$ = 13 TeV is presented. The data correspond to an integrated luminosity of 36 fb$^{-1}$ collected with the CMS detector at the CERN LHC in 2016. A boosted decision tree is used to separate the tW signal from the dominant $\mathrm{t\bar{t}}$ background, whilst the subleading W+jets and multijet backgrounds are constrained using data-based estimates. This result is the first observation of the tW process in final states containing a muon or electron and jets, with a significance exceeding 5 standard deviations. The cross section is determined to be 89 $\pm$ 4 (stat) $\pm$ 12 (syst) pb, consistent with the standard model.

The first observation of the electroweak (EW) production of a Z boson, a photon, and two forward jets (Z$\gamma$jj) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented. A data set corresponding to an integrated luminosity of 137 fb$^{-1}$, collected by the CMS experiment at the LHC in 2016-2018 is used. The measured fiducial cross section for EW Z$\gamma$jj is $\sigma_{\mathrm{EW}}$ = 5.21 $\pm$ 0.52 (stat) $\pm$ 0.56 (syst) fb = 5.21 $\pm$ 0.76 fb. Single-differential cross sections in photon, leading lepton, and leading jet transverse momenta, and double-differential cross sections in $m_{\mathrm{jj}}$ and $\lvert\Delta\eta_{\mathrm{jj}}\rvert$ are also measured. Exclusion limits on anomalous quartic gauge couplings are derived at 95% confidence level in terms of the effective field theory operators $\mathrm{M}_{0}$ to $\mathrm{M}_{5}$, $\mathrm{M}_{7}$, $\mathrm{T}_{0}$ to $\mathrm{T}_{2}$, and $\mathrm{T}_{5}$ to $\mathrm{T}_{9}$.

Measurements of the total and differential fiducial cross sections for the Z boson decaying into two neutrinos are presented at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV. The data were collected by the CMS detector in 2016 and correspond to an integrated luminosity of 35.9 fb$^{-1}$. In these measurements, events are selected containing an imbalance in transverse momentum and one or more energetic jets. The fiducial differential cross section is measured as a function of the Z boson transverse momentum. The results are combined with a previous measurement of charged-lepton decays of the Z boson.