The observation of the production of four top quarks in proton-proton collisions is reported, based on a data sample collected by the CMS experiment at a center-of-mass energy of 13 TeV in 2016-2018 at the CERN LHC and corresponding to an integrated luminosity of 138 fb$^{-1}$. Events with two same-sign, three, or four charged leptons (electrons and muons) and additional jets are analyzed. Compared to previous results in these channels, updated identification techniques for charged leptons and jets originating from the hadronization of b quarks, as well as a revised multivariate analysis strategy to distinguish the signal process from the main backgrounds, lead to an improved expected signal significance of 4.9 standard deviations above the background-only hypothesis. Four top quark production is observed with a significance of 5.6 standard deviations, and its cross section is measured to be 17.7 $^{+3.7}_{-3.5}$ (stat) $^{+2.3}_{-1.9}$ (syst) fb, in agreement with the available standard model predictions.

Three of the most significant measured deviations from standard model predictions, the enhanced decay rate for B $\to$ D$^{(*)}\tau\nu$, hints of lepton universality violation in B $\to$ K$^{(*)}\ell\ell$ decays, and the anomalous magnetic moment of the muon, can be explained by the existence of leptoquarks (LQs) with large couplings to third-generation quarks and masses at the TeV scale. The existence of these states can be probed at the LHC in high energy proton-proton collisions. A novel search is presented for pair production of LQs coupled to a top quark and a muon using data at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{-1}$, recorded by the CMS experiment. No deviation from the standard model prediction has been observed and scalar LQs decaying exclusively into t$\mu$ are excluded up to masses of 1420 GeV. The results of this search are combined with those from previous searches for LQ decays into t$\tau$ and b$\nu$, which excluded scalar LQs below masses of 900 and 1080 GeV. Vector LQs are excluded up to masses of 1190 GeV for all possible combinations of branching fractions to t$\mu$, t$\tau$ and b$\nu$. With this analysis, all relevant couplings of LQs with an electric charge of -1/3 to third-generation quarks are probed for the first time.

A search for resonances decaying into a W boson and a radion, where the radion decays into two W bosons, is presented. The data analyzed correspond to an integrated luminosity of 138 fb$^{-1}$ recorded in proton-proton collisions with the CMS detector at $\sqrt{s} =$ 13 TeV. One isolated charged lepton is required, together with missing transverse momentum and one or two massive large-radius jets, containing the decay products of either two or one W bosons, respectively. No excess over the background estimation is observed. The results are combined with those from a complementary channel with an all-hadronic final state, described in an accompanying paper. Limits are set on parameters of an extended warped extra-dimensional model. These searches are the first of their kind at the LHC.

A search for Kaluza-Klein excited vector boson resonances, $W_\mathrm{KK}$, decaying in cascade to three W bosons via a scalar radion $R, W_\mathrm{KK}\to WR \to WWW$, with two or three massive jets is presented. The search is performed with proton-proton collision data recorded at $\sqrt{s} =$ 13 TeV, collected by the CMS experiment at the CERN LHC, during 2016-2018, corresponding to an integrated luminosity of 138 fb$^{-1}$. Two final states are simultaneously probed, one where the two W bosons produced by the R decay are reconstructed as separate, large-radius, massive jets, and one where they are merged in a single large-radius jet. The observed data are in agreement with the standard model expectations. Limits are set on the product of the $W_\mathrm{KK}$ resonance cross section and branching fraction to three W bosons in an extended warped extra-dimensional model and are the first of their kind at the LHC.

A measurement is reported of the jet mass distribution in hadronic decays of boosted top quarks produced in pp collisions at $\sqrt{s} =$ 13 TeV. The data were collected with the CMS detector at the LHC and correspond to an integrated luminosity of 35.9 fb$^{-1}$. The measurement is performed in the lepton+jets channel of $\mathrm{t\bar{t}}$ events, where the lepton is an electron or muon. The products of the hadronic top quark decay t $\to$ bW $\to$ bq$\mathrm{\bar{q}}'$ are reconstructed as a single jet with transverse momentum larger than 400 GeV. The $\mathrm{t\bar{t}}$ cross section as a function of the jet mass is unfolded at the particle level and used to extract a value of the top quark mass of 172.6 $\pm$ 2.5 GeV. A novel jet reconstruction technique is used for the first time at the LHC, which improves the precision by a factor of three relative to an earlier measurement. This highlights the potential of measurements using boosted top quarks, where the new technique will enable future precision measurements.

The results of a search for Higgs boson pair (HH) production in the WW*WW*, WW*$\tau\tau$, and $\tau\tau\tau\tau$ decay modes are presented. The search uses 138 fb$^{-1}$ of proton-proton collision data recorded by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV from 2016 to 2018. Analyzed events contain two, three, or four reconstructed leptons, including electrons, muons, and hadronically decaying tau leptons. No evidence for a signal is found in the data. Upper limits are set on the cross section for nonresonant HH production, as well as resonant production in which a new heavy particle decays to a pair of Higgs bosons. For nonresonant production, the observed (expected) upper limit on the cross section at 95% confidence level (CL) is 21.3 (19.4) times the standard model (SM) prediction. The observed (expected) ratio of the trilinear Higgs boson self-coupling to its value in the SM is constrained to be within the interval $-$6.9 to 11.1 ($-$6.9 to 11.7) at 95% CL, and limits are set on a variety of new-physics models using an effective field theory approach. The observed (expected) limits on the cross section for resonant HH production range from 0.18 to 0.90 (0.08 to 1.06) pb at 95% CL for new heavy-particle masses in the range 250-1000 GeV.

A search for new heavy particles manifested as resonances in two-jet final states is presented. The data were produced in 7 TeV proton-proton collisions by the Large Hadron Collider (LHC) and correspond to an integrated luminosity of 315 nb^-1 collected by the ATLAS detector. No resonances were observed. Upper limits were set on the product of cross section and signal acceptance for excited-quark (q*) production as a function of q* mass. These exclude at the 95% CL the q* mass interval 0.30 < mq* < 1.26 TeV, extending the reach of previous experiments.

Measurements of the total and differential fiducial cross sections for the Z boson decaying into two neutrinos are presented at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV. The data were collected by the CMS detector in 2016 and correspond to an integrated luminosity of 35.9 fb$^{-1}$. In these measurements, events are selected containing an imbalance in transverse momentum and one or more energetic jets. The fiducial differential cross section is measured as a function of the Z boson transverse momentum. The results are combined with a previous measurement of charged-lepton decays of the Z boson.

A search for the pair production of heavy fermionic partners of the top quark with charge 5/3 (X$_{5/3}$) is performed in proton-proton collisions at a center-of-mass energy of 13 TeV with the CMS detector at the CERN LHC. The data sample analyzed corresponds to an integrated luminosity of 35.9 fb$^{-1}$. The X$_{5/3}$ quark is assumed always to decay into a top quark and a W boson. Both the right-handed and left-handed X$_{5/3}$ couplings to the W boson are considered. Final states with either a pair of same-sign leptons or a single lepton are studied. No significant excess of events is observed above the expected standard model background. Lower limits at 95% confidence level on the X$_{5/3}$ quark mass are set at 1.33 and 1.30 TeV respectively for the case of right-handed and left-handed couplings to W bosons in a combination of the same-sign dilepton and single-lepton final states.

The production cross section of a top quark pair in association with a photon is measured in proton-proton collisions in the decay channel with two oppositely charged leptons (e$^\pm\mu^\mp$, e$^+$e$^-$, or $\mu^+\mu^-$). The measurement is performed using 138 fb$^{-1}$ of proton-proton collision data recorded by the CMS experiment at $\sqrt{s} =$ 13 TeV during the 2016-2018 data-taking period of the CERN LHC. A fiducial phase space is defined such that photons radiated by initial-state particles, top quarks, or any of their decay products are included. An inclusive cross section of 175.2 $\pm$ 2.5 (stat) $\pm$ 6.3 (syst) fb is measured in a signal region with at least one jet coming from the hadronization of a bottom quark and exactly one photon with transverse momentum above 20 GeV. Differential cross sections are measured as functions of several kinematic observables of the photon, leptons, and jets, and compared to standard model predictions. The measurements are also interpreted in the standard model effective field theory framework, and limits are found on the relevant Wilson coefficients from these results alone and in combination with a previous CMS measurement of the $\mathrm{t\bar{t}}\gamma$ production process using the lepton+jets final state.