The first measurements of the production of muons and electrons from heavy-flavour hadron decays in Xe-Xe collisions at $\sqrt{s_{\rm NN}}$ = 5.44 TeV, using the ALICE detector at the LHC, are reported. The measurement of the nuclear modification factor $R_{\rm AA}$ is performed as a function of transverse momentum $p_{\rm T}$ in several centrality classes at forward rapidity ($2.5 < y <4$) and midrapidity ($\vert y \vert < 0.8$) for muons and electrons from heavy-flavour hadron decays, respectively. A suppression by a factor up to about 2.5 compared to the binary-scaled pp reference is observed in central collisions at both central and forward rapidities. The $R_{\rm AA}$ of muons from heavy-flavour hadron decays is compared to previous measurements in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV. When the nuclear modification factors are compared in the centrality classes 0-10% for Xe-Xe collisions and 10-20% for Pb-Pb collisions, which have similar charged-particle multiplicity density, a similar suppression, with $R_{\rm AA} \sim 0.4$ in the $p_{\rm T}$ interval $4 < p_{\rm T} < 8$ GeV/$c$, is observed. The comparison of the measured $R_{\rm AA}$ values in the two collision systems brings new insights on the properties of the quark-gluon plasma by investigating the system-size and path-length dependence of medium-induced parton energy loss. The results of muons and electrons from heavy-flavour hadron decays provide new constraints to model calculations.

The production of $\Upsilon$ mesons in Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}}$ = 5 TeV is measured with the muon spectrometer of the ALICE detector at the LHC. The yields as well as the nuclear modification factors are determined in the forward rapidity region $2.5<y<4.0$, as a function of rapidity, transverse momentum and collision centrality. The results show that the production of the $\Upsilon$(1S) meson is suppressed by a factor of about three with respect to the production in proton-proton collisions. For the first time, a significant signal for the $\Upsilon$(2S) meson is observed at forward rapidity, indicating a suppression stronger by about a factor 2-3 with respect to the ground state. The measurements are compared with transport, hydrodynamic, comover and statistical hadronisation model calculations.

Measurements of the production of muons from heavy-flavour hadron decays in Pb$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = $5.02$ and $2.76$ TeV using the ALICE detector at the LHC are reported. The nuclear modification factor $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 TeV is measured at forward rapidity ($2.5 < y <4$) as a function of transverse momentum $p_{\rm T}$ in central, semi-central, and peripheral collisions over a wide $p_{\rm T}$ interval, $3 < p_{\rm T} < 20$ GeV/$c$, in which muons from beauty-hadron decays are expected to take over from charm as the dominant source at high $p_{\rm T}$ ($p_{\rm T} > 7$ GeV/$c$). The $R_{\rm AA}$ shows an increase of the suppression of the yields of muons from heavy-flavour hadron decays with increasing centrality. A suppression by a factor of about three is observed in the $10\%$ most central collisions. The $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 is similar to that at 2.76 TeV. The precise $R_{\rm AA}$ measurements have the potential to distinguish between model predictions implementing different mechanisms of parton energy loss in the high-density medium formed in heavy-ion collisions. They place important constraints for the understanding of the heavy-quark interaction with the hot and dense QCD medium.

The production of the $\psi(2S)$ charmonium state was measured with ALICE in Pb-Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV, in the dimuon decay channel. A significant signal was observed for the first time at LHC energies down to zero transverse momentum, at forward rapidity ($2.5<y<4$). The measurement of the ratio of the inclusive production cross sections of the $\psi(2S)$ and J/$\psi$ resonances is reported as a function of the centrality of the collisions and of transverse momentum, in the region $p_{\rm T}<12$ GeV/$c$. The results are compared with the corresponding measurements in pp collisions, by forming the double ratio $[\sigma^{\psi(2S)}/\sigma^{J/\psi}]_{\rm{Pb-Pb}}/[\sigma^{\psi(2S)}/\sigma^{J/\psi}]_{\rm{pp}}$. It is found that in Pb-Pb collisions the $\psi(2S)$ is suppressed by a factor of $\sim 2$ with respect to the J/$\psi$. The $\psi(2S)$ nuclear modification factor $R_{\rm AA}$ was also obtained as a function of both centrality and $p_{\rm T}$. The results show that the $\psi(2S)$ resonance yield is strongly suppressed in Pb-Pb collisions, by a factor up to $\sim 3$ with respect to pp. Comparisons of cross section ratios with previous SPS findings by the NA50 experiment and of $R_{\rm AA}$ with higher-$p_{\rm T}$ results at LHC energy are also reported. These results and the corresponding comparisons with calculations of transport and statistical models address questions on the presence and properties of charmonium states in the quark-gluon plasma formed in nuclear collisions at the LHC.

An excess of J/$\psi$ yield at very low transverse momentum ($p_{\rm T} < 0.3$ GeV/$c$), originating from coherent photoproduction, is observed in peripheral and semicentral hadronic Pb$-$Pb collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_{\rm NN}} = 5.02$ TeV. The measurement is performed with the ALICE detector via the dimuon decay channel at forward rapidity ($2.5<y<4$). The nuclear modification factor at very low $p_{\rm T}$ and the coherent photoproduction cross section are measured as a function of centrality down to the 10% most central collisions. These results extend the previous study at $\sqrt{s_{\rm NN}} = 2.76$ TeV, confirming the clear excess over hadronic production in the $p_{\rm T}$ range 0$-$0.3 GeV/$c$ and the centrality range 70$-$90%, and establishing an excess with a significance greater than 5$\sigma$ also in the 50$-$70% and 30$-$50% centrality ranges. The results are compared with earlier measurements at $\sqrt{s_{\rm NN}} = 2.76$ TeV and with different theoretical predictions aiming at describing how coherent photoproduction occurs in hadronic interactions with nuclear overlap.

The production of K$^*$(892)$^\pm$ meson resonance is measured at midrapidity ($|y|<0.5$) in Pb-Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV using the ALICE detector at the LHC. The resonance is reconstructed via its hadronic decay channel K$^*$(892)$^\pm \rightarrow \rm{K^0_S \pi^\pm}$. The transverse momentum distributions are obtained for various centrality intervals in the $p_{\rm T}$ range of 0.4-16 GeV/$c$. The reported measurements of integrated yields, mean transverse momenta, and particle yield ratios are consistent with previous ALICE measurements for K$^*$(892)$^0$. The $p_{\rm T}$-integrated yield ratio 2K$^*$(892)$^\pm$/($\rm{K^+ + K^-}$) in central Pb-Pb collisions shows a significant suppression (9.3$\sigma$) relative to pp collisions. Thermal model calculations overpredict the particle yield ratio. Although both simulations consider the hadronic phase, only HRG-PCE accurately represents the measurements, whereas MUSIC+SMASH tends to overpredict them. These observations, along with the kinetic freeze-out temperatures extracted from the yields of light-flavored hadrons using the HRG-PCE model, indicate a finite hadronic phase lifetime, which increases towards central collisions. The $p_{\rm T}$-differential yield ratios 2K$^*$(892)$^\pm$/($\rm{K^+ + K^-}$) and 2K$^*$(892)$^\pm$/($\rm{\pi^+ + \pi^-}$) are suppressed by up to a factor of five at $p_{\rm T}<2$ GeV/$c$ in central Pb-Pb collisions compared to pp collisions at $\sqrt{s} =$ 5.02 TeV. Both particle ratios and are qualitatively consistent with expectations for rescattering effects in the hadronic phase. The nuclear modification factor shows a smooth evolution with centrality and is below unity at $p_{\rm T}>8$ GeV/$c$, consistent with measurements for other light-flavored hadrons. The smallest values are observed in most central collisions, indicating larger energy loss of partons traversing the dense medium.

The production of non-prompt ${\rm D}^{0}$ mesons from beauty-hadron decays was measured at midrapidity ($\left| y \right| < 0.5$) in Pb-Pb collisions at a nucleon-nucleon center-of-mass energy of $\sqrt{s_{\rm NN}}=5.02~\mathrm{TeV}$ with the ALICE experiment at the LHC. Their nuclear modification factor ($R_{\rm AA}$), measured for the first time down to $p_{\rm T}=1~\mathrm{GeV}/c$ in the $0-10$% and $30-50$% centrality classes, indicates a significant suppression, up to a factor of about three, for $p_{\rm T} > 5~\mathrm{GeV}/c$ in the $0-10$% central Pb-Pb collisions. The data are described by models that include both collisional and radiative processes in the calculation of beauty-quark energy loss in the quark-gluon plasma, and quark recombination in addition to fragmentation as a hadronisation mechanism. The ratio of the non-prompt to prompt ${\rm D}^{0}$-meson $R_{\rm AA}$ is larger than unity for $p_{\rm T} > 4~\mathrm{GeV}/c$ in the $0-10$% central Pb-Pb collisions, as predicted by models in which beauty quarks lose less energy than charm quarks in the quark-gluon plasma because of their larger mass.

The production yield and angular anisotropy of prompt ${D_s^+}$ mesons were measured as a function of transverse momentum ($p_{ T}$) in Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{ NN}} = 5.02$ TeV collected with the ALICE detector at the LHC. ${D_s^+}$ mesons and their charge conjugates were reconstructed at midrapidity ($|y|<0.5$) from their hadronic decay channel ${D_s^+ \to \phi \pi^+}$, with ${\phi \to K^-K^+}$, in the $p_{ T}$ intervals $2<p_{ T}<50$ GeV/$c$ and $2<p_{ T}<36$ GeV/$c$ for the 0-10% and 30-50% centrality intervals. For $p_{ T}>10$ GeV/$c$, the measured ${D_s^+}$-meson nuclear modification factor $R_{ AA}$ is consistent with the one of non-strange D mesons within uncertainties, while at lower $p_{ T}$ a hint for a ${D_s^+}$-meson $R_{ AA}$ larger than that of non-strange D mesons is seen. The enhanced production of ${D_s^+}$ relative to non-strange D mesons is also studied by comparing the $p_{ T}$-dependent ${D_s^+/D^0}$ production yield ratios in Pb-Pb and in pp collisions. The ratio measured in Pb-Pb collisions is found to be on average higher than that in pp collisions in the interval $2<p_{ T} <8$ GeV/$c$ with a significance of 2.3$\sigma$ and 2.4$\sigma$ for the 0-10% and 30-50% centrality intervals. The azimuthal anisotropy coefficient $v_2$ of prompt ${D_s^+}$ mesons was measured in Pb-Pb collisions in the 30-50% centrality interval and is found to be compatible with that of non-strange D mesons. The main features of the measured $R_{ AA}$, ${D_s^+/D^0}$ ratio, and $v_2$ as a function of $p_{ T}$ are described by theoretical calculations of charm-quark transport in a hydrodynamically expanding quark-gluon plasma including hadronisation via charm-quark recombination with light quarks from the medium. The $p_{ T}$-integrated production yield of ${D_s^+}$ mesons is compatible with the prediction of the statistical hadronisation model.

The production of prompt $\rm \Lambda_{\rm c}^{+}$ baryons at midrapidity ($|y|<0.5$) was measured in central (0-10%) and mid-central (30-50%) Pb-Pb collisions at the center-of-mass energy per nucleon-nucleon pair $\sqrt{s_{\rm NN}} = 5.02$ TeV with the ALICE detector. The results are more precise, more differential in centrality, and reach much lower transverse momentum ($p_{\rm T}=1$ GeV/$c$) with respect to previous measurements performed by the ALICE, STAR, and CMS Collaborations in nucleus-nucleus collisions, allowing for an extrapolation down to $p_{\rm T}=0$. The $p_{\rm T}$-differential $\rm \Lambda_{\rm c}^{+}$/D$^0$ production ratio is enhanced with respect to the pp measurement for $4<p_{\rm T}<8$ GeV/$c$ by 3.7 standard deviations ($\sigma$), while the $p_{\rm T}$-integrated ratios are compatible within 1$\sigma$. The observed trend is similar to that observed in the strange sector for the $\Lambda/$K$^0_{\rm S}$ ratio. Model calculations including coalescence or statistical hadronization for charm-hadron formation are compared with the data.

The production of electrons from beauty-hadron decays was measured at midrapidity in proton-proton (pp) and central Pb-Pb collisions at center-of-mass energy per nucleon-nucleon pair $\sqrt{s_{\rm NN}}$ = 5.02 TeV, using the ALICE detector at the LHC. The cross section measured in pp collisions in the transverse momentum interval $2 < p_{\rm T} < 8$ GeV/$c$ was compared with models based on perturbative quantum chromodynamics calculations. The yield in the 10% most central Pb-Pb collisions, measured in the interval $2 < p_{\rm T} < 26$ GeV/$c$, was used to compute the nuclear modification factor $R_{\rm AA}$, extrapolating the pp reference cross section to $p_{\rm T}$ larger than 8 GeV/$c$. The measured $R_{\rm AA}$ shows significant suppression of the yield of electrons from beauty-hadron decays at high $p_{\rm T}$ and does not show a significant dependence on $p_{\rm T}$ above 8 GeV/$c$ within uncertainties. The results are described by several theoretical models based on different implementations of the interaction of heavy quarks with a quark-gluon plasma, which predict a smaller energy loss for beauty quarks compared to light and charm quarks.