This paper presents measurements of charged-hadron spectra obtained in $pp$, $p$+Pb, and Pb+Pb collisions at $\sqrt{s}$ or $\sqrt{s_{_\text{NN}}}=5.02$ TeV, and in Xe+Xe collisions at $\sqrt{s_{_\text{NN}}}=5.44$ TeV. The data recorded by the ATLAS detector at the LHC have total integrated luminosities of 25 pb${}^{-1}$, 28 nb${}^{-1}$, 0.50 nb${}^{-1}$, and 3 $\mu$b${}^{-1}$, respectively. The nuclear modification factors $R_{p\text{Pb}}$ and $R_\text{AA}$ are obtained by comparing the spectra in heavy-ion and $pp$ collisions in a wide range of charged-particle transverse momenta and pseudorapidity. The nuclear modification factor $R_{p\text{Pb}}$ shows a moderate enhancement above unity with a maximum at $p_{\mathrm{T}} \approx 3$ GeV; the enhancement is stronger in the Pb-going direction. The nuclear modification factors in both Pb+Pb and Xe+Xe collisions feature a significant, centrality-dependent suppression. They show a similar distinct $p_{\mathrm{T}}$-dependence with a local maximum at $p_{\mathrm{T}} \approx 2$ GeV and a local minimum at $p_{\mathrm{T}} \approx 7$ GeV. This dependence is more distinguishable in more central collisions. No significant $|\eta|$-dependence is found. A comprehensive comparison with several theoretical predictions is also provided. They typically describe $R_\text{AA}$ better in central collisions and in the $p_{\mathrm{T}}$ range from about 10 to 100 GeV.

Electrons from heavy-flavour hadron decays (charm and beauty) were measured with the ALICE detector in Pb-Pb collisions at a centre-of-mass of energy $\sqrt{s_{\rm NN}}=2.76$ TeV. The transverse momentum ($p_{\rm T}$) differential production yields at mid-rapidity were used to calculate the nuclear modification factor $R_{\rm AA}$ in the interval $3<p_{\rm T}< 18$ GeV/$c$. The $R_{\rm AA}$ shows a strong suppression compared to binary scaling of pp collisions at the same energy (up to a factor of 4) in the 10% most central Pb-Pb collisions. There is a centrality trend of suppression, and a weaker suppression (down to a factor of 2) in semi-peripheral (50-80%) collisions is observed. The suppression of electrons in this broad $p_{\rm T}$ interval indicates that both charm and beauty quarks lose energy when they traverse the hot medium formed in Pb-Pb collisions at LHC.

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark-gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and $pp$ collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadron Collider is presented. The Pb+Pb data were collected in 2015 and 2018 with sampled integrated luminosities of $208~\mathrm{\mu b}^{-1}$ and $38~\mathrm{\mu b^{-1}}$, respectively, and $pp$ data with a sampled integrated luminosity of $1.17~\mathrm{pb}^{-1}$ were collected in 2017. Muons from heavy-flavour semileptonic decays are separated from the light-flavour hadronic background using the momentum imbalance between the inner detector and muon spectrometer measurements, and muons originating from charm and bottom decays are further separated via the muon track's transverse impact parameter. Differential yields in Pb+Pb collisions and differential cross sections in $pp$ collisions for such muons are measured as a function of muon transverse momentum from 4 GeV to 30 GeV in the absolute pseudorapidity interval $|\eta| < 2$. Nuclear modification factors for charm and bottom muons are presented as a function of muon transverse momentum in intervals of Pb+Pb collision centrality. The measured nuclear modification factors quantify a significant suppression of the yields of muons from decays of charm and bottom hadrons, with stronger effects for muons from charm hadron decays.

We report on the first measurement of an excess in the yield of J/$\psi$ at very low transverse momentum ($p_{\rm T}< 0.3$ GeV/$c$) in peripheral hadronic Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV, performed by ALICE at the CERN LHC. Remarkably, the measured nuclear modification factor of J/$\psi$ in the rapidity range $2.5<y<4$ reaches about 7 (2) in the $p_{\rm T}$ range 0-0.3 GeV/$c$ in the 70-90% (50-70%) centrality class. The J/$\psi$ production cross section associated with the observed excess is obtained under the hypothesis that coherent photoproduction of J/$\psi$ is the underlying physics mechanism. If confirmed, the observation of J/$\psi$ coherent photoproduction in Pb-Pb collisions at impact parameters smaller than twice the nuclear radius opens new theoretical and experimental challenges and opportunities. In particular, coherent photoproduction accompanying hadronic collisions may provide insight into the dynamics of photoproduction and nuclear reactions, as well as become a novel probe of the Quark-Gluon Plasma.

The production of prompt $\rm \Lambda_{\rm c}^{+}$ baryons at midrapidity ($|y|<0.5$) was measured in central (0-10%) and mid-central (30-50%) Pb-Pb collisions at the center-of-mass energy per nucleon-nucleon pair $\sqrt{s_{\rm NN}} = 5.02$ TeV with the ALICE detector. The results are more precise, more differential in centrality, and reach much lower transverse momentum ($p_{\rm T}=1$ GeV/$c$) with respect to previous measurements performed by the ALICE, STAR, and CMS Collaborations in nucleus-nucleus collisions, allowing for an extrapolation down to $p_{\rm T}=0$. The $p_{\rm T}$-differential $\rm \Lambda_{\rm c}^{+}$/D$^0$ production ratio is enhanced with respect to the pp measurement for $4<p_{\rm T}<8$ GeV/$c$ by 3.7 standard deviations ($\sigma$), while the $p_{\rm T}$-integrated ratios are compatible within 1$\sigma$. The observed trend is similar to that observed in the strange sector for the $\Lambda/$K$^0_{\rm S}$ ratio. Model calculations including coalescence or statistical hadronization for charm-hadron formation are compared with the data.

The transverse momentum ($p_{\rm T}$) and centrality dependence of the nuclear modification factor $R_{\rm AA}$ of prompt and non-prompt J$/\psi$, the latter originating from the weak decays of beauty hadrons, have been measured by the ALICE collaboration in Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}$ = 5.02 TeV. The measurements are carried out through the ${\rm e}^{+}{\rm e}^{-}$ decay channel at midrapidity ($|y| < 0.9$) in the transverse momentum region $1.5 < p_{\rm T} < 10$ GeV/$c$. Both prompt and non-prompt J$/\psi$ measurements indicate a significant suppression for $p_{\rm T} >$ 5 GeV/$c$, which becomes stronger with increasing collision centrality. The results are consistent with similar LHC measurements in the overlapping $p_{\rm T}$ intervals, and cover the kinematic region down to $p_{\rm T}$ = 1.5 GeV/$c$ at midrapidity, not accessible by other LHC experiments. The suppression of prompt J$/\psi$ in central and semicentral collisions exhibits a decreasing trend towards lower transverse momentum, described within uncertainties by models implementing J$/\psi$ production from recombination of c and $\overline{\rm c}$ quarks produced independently in different partonic scatterings. At high transverse momentum, transport models including quarkonium dissociation are able to describe the suppression for prompt J$/\psi$. For non-prompt J$/\psi$, the suppression predicted by models including both collisional and radiative processes for the computation of the beauty-quark energy loss inside the quark$-$gluon plasma is consistent with measurements within uncertainties.

The production of J/$\psi$ and $\psi(2S)$ was measured with the ALICE detector in Pb-Pb collisions at the LHC. The measurement was performed at forward rapidity ($2.5 < y < 4 $) down to zero transverse momentum ($p_{\rm T}$) in the dimuon decay channel. Inclusive J/$\psi$ yields were extracted in different centrality classes and the centrality dependence of the average $p_{\rm T}$ is presented. The J/$\psi$ suppression, quantified with the nuclear modification factor ($R_{\rm AA}$), was studied as a function of centrality, transverse momentum and rapidity. Comparisons with similar measurements at lower collision energy and theoretical models indicate that the J/$\psi$ production is the result of an interplay between color screening and recombination mechanisms in a deconfined partonic medium, or at its hadronization. Results on the $\psi(2S)$ suppression are provided via the ratio of $\psi(2S)$ over J/$\psi$ measured in pp and Pb-Pb collisions.

Measurements of the production of muons from heavy-flavour hadron decays in Pb$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = $5.02$ and $2.76$ TeV using the ALICE detector at the LHC are reported. The nuclear modification factor $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 TeV is measured at forward rapidity ($2.5 < y <4$) as a function of transverse momentum $p_{\rm T}$ in central, semi-central, and peripheral collisions over a wide $p_{\rm T}$ interval, $3 < p_{\rm T} < 20$ GeV/$c$, in which muons from beauty-hadron decays are expected to take over from charm as the dominant source at high $p_{\rm T}$ ($p_{\rm T} > 7$ GeV/$c$). The $R_{\rm AA}$ shows an increase of the suppression of the yields of muons from heavy-flavour hadron decays with increasing centrality. A suppression by a factor of about three is observed in the $10\%$ most central collisions. The $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 is similar to that at 2.76 TeV. The precise $R_{\rm AA}$ measurements have the potential to distinguish between model predictions implementing different mechanisms of parton energy loss in the high-density medium formed in heavy-ion collisions. They place important constraints for the understanding of the heavy-quark interaction with the hot and dense QCD medium.

The production of non-prompt ${\rm D}^{0}$ mesons from beauty-hadron decays was measured at midrapidity ($\left| y \right| < 0.5$) in Pb-Pb collisions at a nucleon-nucleon center-of-mass energy of $\sqrt{s_{\rm NN}}=5.02~\mathrm{TeV}$ with the ALICE experiment at the LHC. Their nuclear modification factor ($R_{\rm AA}$), measured for the first time down to $p_{\rm T}=1~\mathrm{GeV}/c$ in the $0-10$% and $30-50$% centrality classes, indicates a significant suppression, up to a factor of about three, for $p_{\rm T} > 5~\mathrm{GeV}/c$ in the $0-10$% central Pb-Pb collisions. The data are described by models that include both collisional and radiative processes in the calculation of beauty-quark energy loss in the quark-gluon plasma, and quark recombination in addition to fragmentation as a hadronisation mechanism. The ratio of the non-prompt to prompt ${\rm D}^{0}$-meson $R_{\rm AA}$ is larger than unity for $p_{\rm T} > 4~\mathrm{GeV}/c$ in the $0-10$% central Pb-Pb collisions, as predicted by models in which beauty quarks lose less energy than charm quarks in the quark-gluon plasma because of their larger mass.

The differential invariant yield as a function of transverse momentum ($p_\mathrm{T}$) of electrons from semileptonic heavy-flavour hadron decays was measured at midrapidity in central (0-10%), semi-central (30-50%) and peripheral (60-80%) lead-lead (Pb-Pb) collisions at $\sqrt{s_{\mathrm{NN}}}=5.02\text{ TeV}$ in the $p_{\mathrm{T}}$ intervals 0.5-26 GeV/$c$ (0-10% and 30-50%) and 0.5-10 GeV/$c$ (60-80%). The production cross section in proton-proton (pp) collisions at $\sqrt{s}=5.02$ TeV was measured as well in $0.5<p_\mathrm{T}<10$ GeV/$c$ and it lies close to the upper band of perturbative QCD calculation uncertainties up to $p_\mathrm{T}=5$ GeV/$c$ and close to the mean value for larger $p_\mathrm{T}$. The modification of the electron yield with respect to what is expected for an incoherent superposition of nucleon-nucleon collisions is evaluated by measuring the nuclear modification factor $R_{\mathrm{AA}}$. The measurement of the $R_{\mathrm{AA}}$ in different centrality classes allows in-medium energy loss of charm and beauty quarks to be investigated. The $R_{\mathrm{AA}}$ shows a suppression with respect to unity at intermediate $p_\mathrm{T}$, which increases while moving towards more central collisions. Moreover, the measured $R_{\mathrm{AA}}$ is sensitive to the modification of the parton distribution functions (PDF) in nuclei, like nuclear shadowing, which causes a suppression of the heavy-quark production at low $p_\mathrm{T}$ in heavy-ion collisions at LHC.