The ALICE experiment has measured the inclusive J/$\psi$ production in Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}} } = 2.76$ TeV down to zero transverse momentum in the rapidity range $2.5 < y < 4$. A suppression of the inclusive J/$\psi$ yield in Pb-Pb is observed with respect to the one measured in pp collisions scaled by the number of binary nucleon-nucleon collisions. The nuclear modification factor, integrated over the 0-80% most central collisions, is $0.545 \pm 0.032 \rm{(stat.)} \pm 0.083 \rm{(syst.)}$ and does not exhibit a significant dependence on the collision centrality. These features appear significantly different from measurements at lower collision energies. Models including J/$\psi$ production from charm quarks in a deconfined partonic phase can describe our data.

The inclusive transverse momentum ($p_{\rm T}$) distributions of primary charged particles are measured in the pseudo-rapidity range $|\eta|<0.8$ as a function of event centrality in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}=2.76$ TeV with ALICE at the LHC. The data are presented in the $p_{\rm T}$ range $0.15<p_{\rm T}<50$ GeV/$c$ for nine centrality intervals from 70-80% to 0-5%. The Pb-Pb spectra are presented in terms of the nuclear modification factor $R_{\rm{AA}}$ using a pp reference spectrum measured at the same collision energy. We observe that the suppression of high-$p_{\rm T}$ particles strongly depends on event centrality. In central collisions (0-5%) the yield is most suppressed with $R_{\rm{AA}}\approx0.13$ at $p_{\rm T}=6$-7 GeV/$c$. Above $p_{\rm T}=7$ GeV/$c$, there is a significant rise in the nuclear modification factor, which reaches $R_{\rm{AA}} \approx0.4$ for $p_{\rm T}>30$ GeV/$c$. In peripheral collisions (70-80%), the suppression is weaker with $R_{\rm{AA}} \approx 0.7$ almost independently of $p_{\rm T}$. The measured nuclear modification factors are compared to other measurements and model calculations.

The ALICE Collaboration has measured the inclusive production of muons from heavy flavour decays at forward rapidity, 2.5 < y < 4, in pp and Pb-Pb collisions at $\sqrt {s_{NN}}$ = 2.76 TeV. The $p_{\rm T}$-differential inclusive cross section of muons from heavy flavour decays in pp collisions is compared to perturbative QCD calculations. The nuclear modification factor is studied as a function of pt and collision centrality. A weak suppression is measured in peripheral collisions. In the most central collisions, a suppression of a factor of about 3-4 is observed in 6 < $p_{\rm T}$ < 10 GeV/$c$. The suppression shows no significant $p_{\rm T}$ dependence.

The production of the $\psi(2S)$ charmonium state was measured with ALICE in Pb-Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV, in the dimuon decay channel. A significant signal was observed for the first time at LHC energies down to zero transverse momentum, at forward rapidity ($2.5<y<4$). The measurement of the ratio of the inclusive production cross sections of the $\psi(2S)$ and J/$\psi$ resonances is reported as a function of the centrality of the collisions and of transverse momentum, in the region $p_{\rm T}<12$ GeV/$c$. The results are compared with the corresponding measurements in pp collisions, by forming the double ratio $[\sigma^{\psi(2S)}/\sigma^{J/\psi}]_{\rm{Pb-Pb}}/[\sigma^{\psi(2S)}/\sigma^{J/\psi}]_{\rm{pp}}$. It is found that in Pb-Pb collisions the $\psi(2S)$ is suppressed by a factor of $\sim 2$ with respect to the J/$\psi$. The $\psi(2S)$ nuclear modification factor $R_{\rm AA}$ was also obtained as a function of both centrality and $p_{\rm T}$. The results show that the $\psi(2S)$ resonance yield is strongly suppressed in Pb-Pb collisions, by a factor up to $\sim 3$ with respect to pp. Comparisons of cross section ratios with previous SPS findings by the NA50 experiment and of $R_{\rm AA}$ with higher-$p_{\rm T}$ results at LHC energy are also reported. These results and the corresponding comparisons with calculations of transport and statistical models address questions on the presence and properties of charmonium states in the quark-gluon plasma formed in nuclear collisions at the LHC.

The first measurements of the production of muons and electrons from heavy-flavour hadron decays in Xe-Xe collisions at $\sqrt{s_{\rm NN}}$ = 5.44 TeV, using the ALICE detector at the LHC, are reported. The measurement of the nuclear modification factor $R_{\rm AA}$ is performed as a function of transverse momentum $p_{\rm T}$ in several centrality classes at forward rapidity ($2.5 < y <4$) and midrapidity ($\vert y \vert < 0.8$) for muons and electrons from heavy-flavour hadron decays, respectively. A suppression by a factor up to about 2.5 compared to the binary-scaled pp reference is observed in central collisions at both central and forward rapidities. The $R_{\rm AA}$ of muons from heavy-flavour hadron decays is compared to previous measurements in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV. When the nuclear modification factors are compared in the centrality classes 0-10% for Xe-Xe collisions and 10-20% for Pb-Pb collisions, which have similar charged-particle multiplicity density, a similar suppression, with $R_{\rm AA} \sim 0.4$ in the $p_{\rm T}$ interval $4 < p_{\rm T} < 8$ GeV/$c$, is observed. The comparison of the measured $R_{\rm AA}$ values in the two collision systems brings new insights on the properties of the quark-gluon plasma by investigating the system-size and path-length dependence of medium-induced parton energy loss. The results of muons and electrons from heavy-flavour hadron decays provide new constraints to model calculations.

Jet production in lead-lead (PbPb) and proton-proton (pp) collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV is studied with the CMS detector at the LHC, using PbPb and pp data samples corresponding to integrated luminosities of 404 $\mu$b$^{-1}$ and 27.4 pb$^{-1}$, respectively. Jets with different areas are reconstructed using the anti-$k_\mathrm{T}$ algorithm by varying the distance parameter $R$. The measurements are performed using jets with transverse momenta ($p_\mathrm{T}$) greater than 200 GeV and in a pseudorapidity range of $|\eta|$$\lt$ 2. To reveal the medium modification of the jet spectra in PbPb collisions, the properly normalized ratio of spectra from PbPb and pp data is used to extract jet nuclear modification factors as functions of the PbPb collision centrality, $p_\mathrm{T}$ and, for the first time, as a function of $R$ up to 1.0. For the most central collisions, a strong suppression is observed for high-$p_\mathrm{T}$ jets reconstructed with all distance parameters, implying that a significant amount of jet energy is scattered to large angles. The dependence of jet suppression on $R$ is expected to be sensitive to both the jet energy loss mechanism and the medium response, and so the data are compared to several modern event generators and analytic calculations. The models considered do not fully reproduce the data.

The production yield and angular anisotropy of prompt ${D_s^+}$ mesons were measured as a function of transverse momentum ($p_{ T}$) in Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{ NN}} = 5.02$ TeV collected with the ALICE detector at the LHC. ${D_s^+}$ mesons and their charge conjugates were reconstructed at midrapidity ($|y|<0.5$) from their hadronic decay channel ${D_s^+ \to \phi \pi^+}$, with ${\phi \to K^-K^+}$, in the $p_{ T}$ intervals $2<p_{ T}<50$ GeV/$c$ and $2<p_{ T}<36$ GeV/$c$ for the 0-10% and 30-50% centrality intervals. For $p_{ T}>10$ GeV/$c$, the measured ${D_s^+}$-meson nuclear modification factor $R_{ AA}$ is consistent with the one of non-strange D mesons within uncertainties, while at lower $p_{ T}$ a hint for a ${D_s^+}$-meson $R_{ AA}$ larger than that of non-strange D mesons is seen. The enhanced production of ${D_s^+}$ relative to non-strange D mesons is also studied by comparing the $p_{ T}$-dependent ${D_s^+/D^0}$ production yield ratios in Pb-Pb and in pp collisions. The ratio measured in Pb-Pb collisions is found to be on average higher than that in pp collisions in the interval $2<p_{ T} <8$ GeV/$c$ with a significance of 2.3$\sigma$ and 2.4$\sigma$ for the 0-10% and 30-50% centrality intervals. The azimuthal anisotropy coefficient $v_2$ of prompt ${D_s^+}$ mesons was measured in Pb-Pb collisions in the 30-50% centrality interval and is found to be compatible with that of non-strange D mesons. The main features of the measured $R_{ AA}$, ${D_s^+/D^0}$ ratio, and $v_2$ as a function of $p_{ T}$ are described by theoretical calculations of charm-quark transport in a hydrodynamically expanding quark-gluon plasma including hadronisation via charm-quark recombination with light quarks from the medium. The $p_{ T}$-integrated production yield of ${D_s^+}$ mesons is compatible with the prediction of the statistical hadronisation model.

The nuclear modification factors of J/$\psi$ and $\psi$(2S) mesons are measured in PbPb collisions at a centre-of-mass energy per nucleon pair of $\sqrt{s_{\mathrm{NN}}} =$ 5.02 TeV. The analysis is based on PbPb and pp data samples collected by CMS at the LHC in 2015, corresponding to integrated luminosities of 464 $\mu$b$^{-1}$ and 28 pb$^{-1}$, respectively. The measurements are performed in the dimuon rapidity range of $|y| <$ 2.4 as a function of centrality, rapidity, and transverse momentum (p$_\mathrm{T}$) from p$_\mathrm{T}=$ 3 GeV/$c$ in the most forward region and up to 50 GeV/$c$. Both prompt and nonprompt (coming from b hadron decays) mesons are observed to be increasingly suppressed with centrality, with a magnitude similar to the one observed at $\sqrt{s_{\mathrm{NN}}}=$ 2.76 TeV for the two J/$\psi$ meson components. No dependence on rapidity is observed for either prompt or nonprompt J/$\psi$ mesons. An indication of a lower prompt J/$\psi$ meson suppression at p$_\mathrm{T} >$ 25 GeV/$c$ is seen with respect to that observed at intermediate p$_\mathrm{T}$. The prompt $\psi$(2S) meson yield is found to be more suppressed than that of the prompt J/$\psi$ mesons in the entire p$_\mathrm{T}$ range.

The production of jets associated to bottom quarks is measured for the first time in PbPb collisions at a center-of-mass energy of 2.76 TeV per nucleon pair. Jet spectra are reported in the transverse momentum (pt) range of 80-250 GeV, and within pseudorapidity abs(eta < 2). The nuclear modification factor (R[AA]) calculated from these spectra shows a strong suppression in the b-jet yield in PbPb collisions relative to the yield observed in pp collisions at the same energy. The suppression persists to the largest values of pt studied, and is centrality dependent. The R[AA] is about 0.4 in the most central events, similar to previous observations for inclusive jets. This implies that jet quenching does not have a strong dependence on parton mass and flavor in the jet pt range studied.

The $B_\mathrm{c}^+$ meson is observed for the first time in heavy ion collisions. Data from the CMS detector are used to study the production of the $B_\mathrm{c}^+$ meson in lead-lead (PbPb) and proton-proton (pp) collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_{\mathrm{NN}}} =$ 5.02 TeV, via the $B_\mathrm{c}^+ \to (J/\psi\to\mu^+\mu^-)\mu^+\nu_\mu$ decay. The $B_\mathrm{c}^+$ nuclear modification factor, derived from the PbPb-to-pp ratio of production cross sections, is measured in two bins of the trimuon transverse momentum and of the PbPb collision centrality. The B$_\mathrm{c}^+$ meson is shown to be less suppressed than quarkonia and most of the open heavy-flavor mesons, suggesting that effects of the hot and dense nuclear matter created in heavy ion collisions contribute to its production. This measurement sets forth a promising new probe of the interplay of suppression and enhancement mechanisms in the production of heavy-flavor mesons in the quark-gluon plasma.