The cross sections for $\Upsilon$(1S), $\Upsilon$(2S), and $\Upsilon$(3S) production in lead-lead (PbPb) and proton-proton (pp) collisions at $\sqrt{s_{_\mathrm{NN}}} =$ 5.02 TeV have been measured using the CMS detector at the LHC. The nuclear modification factors, R$_\mathrm{AA}$, derived from the PbPb-to-pp ratio of yields for each state, are studied as functions of meson rapidity and transverse momentum, as well as PbPb collision centrality. The yields of all three states are found to be significantly suppressed, and compatible with a sequential ordering of the suppression, R$_\mathrm{AA}$($\Upsilon$(1S)) $>$ R$_\mathrm{AA}$($\Upsilon$(2S)) $>$ R$_\mathrm{AA}$($\Upsilon$(3S)) . The suppression of $\Upsilon$(1S) is larger than that seen at $\sqrt{s_{_\mathrm{NN}}} =$ 2.76 TeV, although the two are compatible within uncertainties. The upper limit on the R$_\mathrm{AA}$ of $\Upsilon$(3S) integrated over $p_\mathrm{T}$ and rapidity is 0.094 at 95% confidence level, which is the strongest suppression observed for any hadron species in heavy ion collisions to date.

The production of prompt $\Lambda^+_\mathrm{c}$ baryons is measured via the exclusive decay channel $\Lambda^+_\mathrm{c}$$\to$ pK$^-\pi^+$ at a center-of-mass energy per nucleon pair of 5.02 TeV, using proton-proton (pp) and lead-lead (PbPb) collision data collected by the CMS experiment at the CERN LHC. The pp and PbPb data were obtained in 2017 and 2018 with integrated luminosities of 252 and 0.607 nb$^{-1}$, respectively. The measurements are performed within the $\Lambda^+_\mathrm{c}$ rapidity interval $\vert y \vert$$\lt$ 1 with transverse momentum ($p_\mathrm{T}$) ranges of 3-30 and 6-40 GeV/$c$ for pp and PbPb collisions, respectively. Compared to the yields in pp collisions scaled by the expected number of nucleon-nucleon interactions, the observed yields of $\Lambda^+_\mathrm{c}$ with $p_\mathrm{T}$$\gt$ 10 GeV/$c$ are strongly suppressed in PbPb collisions. The level of suppression depends significantly on the collision centrality. The $\Lambda^+_\mathrm{c}$ / D$^0$ production ratio is similar in PbPb and pp collisions at $p_\mathrm{T}$$\gt$ 10 GeV/$c$, suggesting that the coalescence process does not play a dominant role in prompt $\Lambda^+_\mathrm{c}$ baryon production at higher $p_\mathrm{T}$.

The ratio between the prompt psi(2S) and J/psi yields, reconstructed via their decays into muon pairs, is measured in PbPb and pp collisions at sqrt(s[NN]) = 2.76 TeV. The analysis is based on PbPb and pp data samples collected by CMS at the LHC, corresponding to integrated luminosities of 150 inverse microbarns and 5.4 inverse picobarns, respectively. The double ratio of measured yields, (N[psi(2S)]/N[J/psi])[PbPb] / (N[psi(2S)]/ N[J/psi])[pp], is computed in three PbPb collision centrality bins and two kinematic ranges: one at midrapidity, abs(y) < 1.6, covering the transverse momentum range 6.5 < pt < 30 GeV/c, and the other at forward rapidity, 1.6 < abs(y) < 2.4, extending to lower pt values, 3 < pt < 30 GeV/c. The centrality-integrated double ratio changes from 0.45 +/- 0.13 (stat) +/- 0.07 (syst) in the first range to 1.67 +/- 0.34 (stat) +/- 0.27 (syst) in the second. This difference is most pronounced in the most central collisions.

The production of $\Upsilon$(2S) and $\Upsilon$(3S) mesons in lead-lead (PbPb) and proton-proton (pp) collisions is studied in their dimuon decay channel using the CMS detector at the LHC. The $\Upsilon$(3S) meson is observed for the first time in PbPb collisions, with a significance above five standard deviations. The ratios of yields measured in PbPb and pp collisions are reported for both the $\Upsilon$(2S) and $\Upsilon$(3S) mesons, as functions of transverse momentum and PbPb collision centrality. These ratios, when appropriately scaled, are significantly less than unity, indicating a suppression of $\Upsilon$ yields in PbPb collisions. This suppression increases from peripheral to central PbPb collisions. Furthermore, the suppression is stronger for $\Upsilon$(3S) mesons compared to $\Upsilon$(2S) mesons, extending the pattern of sequential suppression of quarkonium states in nuclear collisions previously seen for the $\psi$/J, $\psi$(2S), $\Upsilon$(1S), and $\Upsilon$(2S) mesons.

The nuclear modification factor RAA and the azimuthal anisotropy coefficient v[2] of prompt and nonprompt (i.e. those from decays of b hadrons) J/psi mesons, measured from PbPb and pp collisions at sqrt(s[NN]) = 2.76 TeV at the LHC, are reported. The results are presented in several event centrality intervals and several kinematic regions, for transverse momenta pt > 6.5 GeV/c and rapidity abs(y) < 2.4, extending down to pt = 3 GeV/c in the 1.6 < abs(y) < 2.4 range. The v[2] of prompt J/psi is found to be nonzero, but with no strong dependence on centrality, rapidity, or pt over the full kinematic range studied. The measured v[2] of nonprompt J/psi is consistent with zero. The RAA of prompt J/psi exhibits a suppression that increases from peripheral to central collisions but does not vary as a function of either y or pt in the fiducial range. The nonprompt J/psi RAA shows a suppression which becomes stronger as rapidity or pt increase. The v[2] and nuclear suppression of open and hidden charm, and of open charm and beauty, are compared.

The differential cross sections of $\Lambda_\mathrm{c}^+$ baryon production are measured via the exclusive decay channel $\Lambda_\mathrm{c}^+ \to $pK$^-\pi^+$, as a function of transverse momentum ($p_\mathrm{T}$) in proton-proton (pp) and lead-lead (PbPb) collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV with the CMS detector at the LHC. The measurement is performed within the $\Lambda_\mathrm{c}^+$ rapidity interval $|y|<$1.0 in the $p_\mathrm{T}$ range of 5-20 GeV/$c$ in pp and 10-20 GeV/$c$ in PbPb collisions. The observed yields of $\Lambda_\mathrm{c}^+$ for $p_\mathrm{T}$ of 10-20 GeV/$c$ suggest a possible suppression in central PbPb collisions compared to pp collisions. The $\Lambda_\mathrm{c}^+/$D$^0$ production ratio in pp collisions is compared to theoretical models. In PbPb collisions, this ratio is consistent with the result from pp collisions in their common $p_\mathrm{T}$ range.

The production yields of Upsilon(1S), Upsilon(2S), and Upsilon(3S) quarkonium states are measured through their decays into muon pairs in the CMS detector, in PbPb and pp collisions at the centre-of-mass energy per nucleon pair of 2.76 TeV. The data correspond to integrated luminosities of 166 inverse microbarns and 5.4 inverse picobarns for PbPb and pp collisions, respectively. Differential production cross sections are reported as functions of Upsilon rapidity y up to 2.4, and transverse momentum pT up to 20 GeV/c. A strong centrality-dependent suppression is observed in PbPb relative to pp collisions, by factors of up to approximately 2 and 8, for the Upsilon(1S) and Upsilon(2S) states, respectively. No significant dependence of this suppression is observed as a function of y or pT. The Upsilon(3S) state is not observed in PbPb collisions, which corresponds to a suppression for the centrality-integrated data by at least a factor of approximately 7 at a 95% confidence level. The observed suppression is in agreement with theoretical scenarios modeling the sequential melting of quarkonium states in a quark gluon plasma.

The $B_\mathrm{c}^+$ meson is observed for the first time in heavy ion collisions. Data from the CMS detector are used to study the production of the $B_\mathrm{c}^+$ meson in lead-lead (PbPb) and proton-proton (pp) collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_{\mathrm{NN}}} =$ 5.02 TeV, via the $B_\mathrm{c}^+ \to (J/\psi\to\mu^+\mu^-)\mu^+\nu_\mu$ decay. The $B_\mathrm{c}^+$ nuclear modification factor, derived from the PbPb-to-pp ratio of production cross sections, is measured in two bins of the trimuon transverse momentum and of the PbPb collision centrality. The B$_\mathrm{c}^+$ meson is shown to be less suppressed than quarkonia and most of the open heavy-flavor mesons, suggesting that effects of the hot and dense nuclear matter created in heavy ion collisions contribute to its production. This measurement sets forth a promising new probe of the interplay of suppression and enhancement mechanisms in the production of heavy-flavor mesons in the quark-gluon plasma.

The transverse momentum spectra of charged particles have been measured in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV by the CMS experiment at the LHC. In the transverse momentum range pt = 5-10 GeV/c, the charged particle yield in the most central PbPb collisions is suppressed by up to a factor of 5 compared to the pp yield scaled by the number of incoherent nucleon-nucleon collisions. At higher pt, this suppression is significantly reduced, approaching roughly a factor of 2 for particles with pt in the range pt=40-100 GeV/c.

A search for Z bosons in the mu^+mu^- decay channel has been performed in PbPb collisions at a nucleon-nucleon centre of mass energy = 2.76 TeV with the CMS detector at the LHC, in a 7.2 inverse microbarn data sample. The number of opposite-sign muon pairs observed in the 60--120 GeV/c2 invariant mass range is 39, corresponding to a yield per unit of rapidity (y) and per minimum bias event of (33.8 ± 5.5 (stat) ± 4.4 (syst)) 10^{-8}, in the |y|<2.0 range. Rapidity, transverse momentum, and centrality dependencies are also measured. The results agree with next-to-leading order QCD calculations, scaled by the number of incoherent nucleon-nucleon collisions.