This paper presents measurements of charged-hadron spectra obtained in $pp$, $p$+Pb, and Pb+Pb collisions at $\sqrt{s}$ or $\sqrt{s_{_\text{NN}}}=5.02$ TeV, and in Xe+Xe collisions at $\sqrt{s_{_\text{NN}}}=5.44$ TeV. The data recorded by the ATLAS detector at the LHC have total integrated luminosities of 25 pb${}^{-1}$, 28 nb${}^{-1}$, 0.50 nb${}^{-1}$, and 3 $\mu$b${}^{-1}$, respectively. The nuclear modification factors $R_{p\text{Pb}}$ and $R_\text{AA}$ are obtained by comparing the spectra in heavy-ion and $pp$ collisions in a wide range of charged-particle transverse momenta and pseudorapidity. The nuclear modification factor $R_{p\text{Pb}}$ shows a moderate enhancement above unity with a maximum at $p_{\mathrm{T}} \approx 3$ GeV; the enhancement is stronger in the Pb-going direction. The nuclear modification factors in both Pb+Pb and Xe+Xe collisions feature a significant, centrality-dependent suppression. They show a similar distinct $p_{\mathrm{T}}$-dependence with a local maximum at $p_{\mathrm{T}} \approx 2$ GeV and a local minimum at $p_{\mathrm{T}} \approx 7$ GeV. This dependence is more distinguishable in more central collisions. No significant $|\eta|$-dependence is found. A comprehensive comparison with several theoretical predictions is also provided. They typically describe $R_\text{AA}$ better in central collisions and in the $p_{\mathrm{T}}$ range from about 10 to 100 GeV.

A measurement of $J/\psi$ and $\psi(2\mathrm{S})$ production is presented. It is based on a data sample from Pb+Pb collisions at $\sqrt{s_{\mathrm{NN}}}$ = 5.02 TeV and $pp$ collisions at $\sqrt{s}$ = 5.02 TeV recorded by the ATLAS detector at the LHC in 2015, corresponding to an integrated luminosity of $0.42\mathrm{nb}^{-1}$ and $25\mathrm{pb}^{-1}$ in Pb+Pb and $pp$, respectively. The measurements of per-event yields, nuclear modification factors, and non-prompt fractions are performed in the dimuon decay channel for $9 < p_{T}^{\mu\mu} < 40$ GeV in dimuon transverse momentum, and $-2.0 < y_{\mu\mu} < 2.0$ in rapidity. Strong suppression is found in Pb+Pb collisions for both prompt and non-prompt $J/\psi$, as well as for prompt and non-prompt $\psi(2\mathrm{S})$, increasing with event centrality. The suppression of prompt $\psi(2\mathrm{S})$ is observed to be stronger than that of $J/\psi$, while the suppression of non-prompt $\psi(2\mathrm{S})$ is equal to that of the non-prompt $J/\psi$ within uncertainties, consistent with the expectation that both arise from \textit{b}-quarks propagating through the medium. Despite prompt and non-prompt $J/\psi$ arising from different mechanisms, the dependence of their nuclear modification factors on centrality is found to be quite similar.

Measurements of the production of muons from heavy-flavour hadron decays in Pb$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = $5.02$ and $2.76$ TeV using the ALICE detector at the LHC are reported. The nuclear modification factor $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 TeV is measured at forward rapidity ($2.5 < y <4$) as a function of transverse momentum $p_{\rm T}$ in central, semi-central, and peripheral collisions over a wide $p_{\rm T}$ interval, $3 < p_{\rm T} < 20$ GeV/$c$, in which muons from beauty-hadron decays are expected to take over from charm as the dominant source at high $p_{\rm T}$ ($p_{\rm T} > 7$ GeV/$c$). The $R_{\rm AA}$ shows an increase of the suppression of the yields of muons from heavy-flavour hadron decays with increasing centrality. A suppression by a factor of about three is observed in the $10\%$ most central collisions. The $R_{\rm AA}$ at $\sqrt{s_{\rm NN}}$ = 5.02 is similar to that at 2.76 TeV. The precise $R_{\rm AA}$ measurements have the potential to distinguish between model predictions implementing different mechanisms of parton energy loss in the high-density medium formed in heavy-ion collisions. They place important constraints for the understanding of the heavy-quark interaction with the hot and dense QCD medium.

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark-gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and $pp$ collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadron Collider is presented. The Pb+Pb data were collected in 2015 and 2018 with sampled integrated luminosities of $208~\mathrm{\mu b}^{-1}$ and $38~\mathrm{\mu b^{-1}}$, respectively, and $pp$ data with a sampled integrated luminosity of $1.17~\mathrm{pb}^{-1}$ were collected in 2017. Muons from heavy-flavour semileptonic decays are separated from the light-flavour hadronic background using the momentum imbalance between the inner detector and muon spectrometer measurements, and muons originating from charm and bottom decays are further separated via the muon track's transverse impact parameter. Differential yields in Pb+Pb collisions and differential cross sections in $pp$ collisions for such muons are measured as a function of muon transverse momentum from 4 GeV to 30 GeV in the absolute pseudorapidity interval $|\eta| < 2$. Nuclear modification factors for charm and bottom muons are presented as a function of muon transverse momentum in intervals of Pb+Pb collision centrality. The measured nuclear modification factors quantify a significant suppression of the yields of muons from decays of charm and bottom hadrons, with stronger effects for muons from charm hadron decays.

The inclusive J/$\psi$ meson production in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision of $\sqrt{s_{\rm NN}}$ = 5.02 TeV at midrapidity ($|y|$ < 0.9) is reported by the ALICE Collaboration. The measurements are performed in the dielectron decay channel, as a function of event centrality and J/$\psi$ transverse momentum $p_{\rm T}$, down to $p_{\rm T}$ = 0 GeV/$c$. The J/$\psi$ mean transverse momentum $\langle p_{\rm T} \rangle$ and $r_{\rm AA}$ ratio, defined as $\langle p^{\rm 2}_{\rm T} \rangle_{\rm PbPb}/\langle p^{\rm 2}_{\rm T} \rangle_{\rm pp}$, are evaluated. Both observables show a centrality dependence decreasing towards central (head-on) collisions. The J/$\psi$ nuclear modification factor $R_{\rm AA}$ exhibits a strong $p_{\rm T}$ dependence with a large suppression at high $p_{\rm T}$ and an increase to unity for decreasing $p_{\rm T}$. When integrating over the measured momentum range $p_{\rm T}$ < 10 GeV/$c$, the J/$\psi$ $R_{\rm AA}$ shows a weak centrality dependence. Each measurement is compared with results at lower center-of-mass energies and with ALICE measurements at forward rapidity, as well as to theory calculations. All reported features of the J/$\psi$ production at low $p_{\rm T}$ are consistent with a dominant contribution to the J/$\psi$ yield originating from charm quark (re)combination.

The production of prompt $\rm \Lambda_{\rm c}^{+}$ baryons at midrapidity ($|y|<0.5$) was measured in central (0-10%) and mid-central (30-50%) Pb-Pb collisions at the center-of-mass energy per nucleon-nucleon pair $\sqrt{s_{\rm NN}} = 5.02$ TeV with the ALICE detector. The results are more precise, more differential in centrality, and reach much lower transverse momentum ($p_{\rm T}=1$ GeV/$c$) with respect to previous measurements performed by the ALICE, STAR, and CMS Collaborations in nucleus-nucleus collisions, allowing for an extrapolation down to $p_{\rm T}=0$. The $p_{\rm T}$-differential $\rm \Lambda_{\rm c}^{+}$/D$^0$ production ratio is enhanced with respect to the pp measurement for $4<p_{\rm T}<8$ GeV/$c$ by 3.7 standard deviations ($\sigma$), while the $p_{\rm T}$-integrated ratios are compatible within 1$\sigma$. The observed trend is similar to that observed in the strange sector for the $\Lambda/$K$^0_{\rm S}$ ratio. Model calculations including coalescence or statistical hadronization for charm-hadron formation are compared with the data.

Measurements of the yield and nuclear modification factor, $R_\mathrm{ AA}$, for inclusive jet production are performed using 0.49 nb$^{-1}$ of Pb+Pb data at $\sqrt{s_\mathrm{NN}} = 5.02$ TeV and 25 pb$^{-1}$ of $pp$ data at $\sqrt{s}=5.02$ TeV with the ATLAS detector at the LHC. Jets are reconstructed with the anti-$k_t$ algorithm with radius parameter $R=0.4$ and are measured over the transverse momentum range of 40-1000 GeV in six rapidity intervals covering $|y|<2.8$. The magnitude of $R_\mathrm{ AA}$ increases with increasing jet transverse momentum, reaching a value of approximately 0.6 at 1 TeV in the most central collisions. The magnitude of $R_\mathrm{ AA}$ also increases towards peripheral collisions. The value of $R_\mathrm{ AA}$ is independent of rapidity at low jet transverse momenta, but it is observed to decrease with increasing rapidity at high transverse momenta.

The production of non-prompt ${\rm D}^{0}$ mesons from beauty-hadron decays was measured at midrapidity ($\left| y \right| < 0.5$) in Pb-Pb collisions at a nucleon-nucleon center-of-mass energy of $\sqrt{s_{\rm NN}}=5.02~\mathrm{TeV}$ with the ALICE experiment at the LHC. Their nuclear modification factor ($R_{\rm AA}$), measured for the first time down to $p_{\rm T}=1~\mathrm{GeV}/c$ in the $0-10$% and $30-50$% centrality classes, indicates a significant suppression, up to a factor of about three, for $p_{\rm T} > 5~\mathrm{GeV}/c$ in the $0-10$% central Pb-Pb collisions. The data are described by models that include both collisional and radiative processes in the calculation of beauty-quark energy loss in the quark-gluon plasma, and quark recombination in addition to fragmentation as a hadronisation mechanism. The ratio of the non-prompt to prompt ${\rm D}^{0}$-meson $R_{\rm AA}$ is larger than unity for $p_{\rm T} > 4~\mathrm{GeV}/c$ in the $0-10$% central Pb-Pb collisions, as predicted by models in which beauty quarks lose less energy than charm quarks in the quark-gluon plasma because of their larger mass.

The production yield and angular anisotropy of prompt ${D_s^+}$ mesons were measured as a function of transverse momentum ($p_{ T}$) in Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{ NN}} = 5.02$ TeV collected with the ALICE detector at the LHC. ${D_s^+}$ mesons and their charge conjugates were reconstructed at midrapidity ($|y|<0.5$) from their hadronic decay channel ${D_s^+ \to \phi \pi^+}$, with ${\phi \to K^-K^+}$, in the $p_{ T}$ intervals $2<p_{ T}<50$ GeV/$c$ and $2<p_{ T}<36$ GeV/$c$ for the 0-10% and 30-50% centrality intervals. For $p_{ T}>10$ GeV/$c$, the measured ${D_s^+}$-meson nuclear modification factor $R_{ AA}$ is consistent with the one of non-strange D mesons within uncertainties, while at lower $p_{ T}$ a hint for a ${D_s^+}$-meson $R_{ AA}$ larger than that of non-strange D mesons is seen. The enhanced production of ${D_s^+}$ relative to non-strange D mesons is also studied by comparing the $p_{ T}$-dependent ${D_s^+/D^0}$ production yield ratios in Pb-Pb and in pp collisions. The ratio measured in Pb-Pb collisions is found to be on average higher than that in pp collisions in the interval $2<p_{ T} <8$ GeV/$c$ with a significance of 2.3$\sigma$ and 2.4$\sigma$ for the 0-10% and 30-50% centrality intervals. The azimuthal anisotropy coefficient $v_2$ of prompt ${D_s^+}$ mesons was measured in Pb-Pb collisions in the 30-50% centrality interval and is found to be compatible with that of non-strange D mesons. The main features of the measured $R_{ AA}$, ${D_s^+/D^0}$ ratio, and $v_2$ as a function of $p_{ T}$ are described by theoretical calculations of charm-quark transport in a hydrodynamically expanding quark-gluon plasma including hadronisation via charm-quark recombination with light quarks from the medium. The $p_{ T}$-integrated production yield of ${D_s^+}$ mesons is compatible with the prediction of the statistical hadronisation model.

The production of $\Upsilon$ mesons in Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}}$ = 5 TeV is measured with the muon spectrometer of the ALICE detector at the LHC. The yields as well as the nuclear modification factors are determined in the forward rapidity region $2.5<y<4.0$, as a function of rapidity, transverse momentum and collision centrality. The results show that the production of the $\Upsilon$(1S) meson is suppressed by a factor of about three with respect to the production in proton-proton collisions. For the first time, a significant signal for the $\Upsilon$(2S) meson is observed at forward rapidity, indicating a suppression stronger by about a factor 2-3 with respect to the ground state. The measurements are compared with transport, hydrodynamic, comover and statistical hadronisation model calculations.